Print page    

Publications

  1. The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.
    Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E, Sprangers R.
    EMBO J
    . 2011 Nov 15;31(2):279-90. doi: 10.1038/emboj.2011.408. Pubmed
  2. Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings. Mund M, Neu A, Ullmann J, Neu U, Sprangers R. J Mol Biol. 2011 Nov 25;414(2):165-76. Epub 2011 Oct 6. PMID: 22001694. PubMed
  3. Sheppard D, Sprangers R & Tugarinov V (2010) Experimental approaches for NMR studies of side-chain dynamics in high-molecular-weight proteins. Prog Nucl Magn Reson Spectrosc 56, 1-45. PubMed
  4. Religa TL, Sprangers R & Kay LE (2010) Dynamic regulation of archaeal proteasome gate opening as studied by TROSY NMR. Science 328, 98-102. PubMed
  5. Li X, Wood TE, Sprangers R, Jansen G, Franke NE, Mao X, Wang X, Zhang Y, Verbrugge SE, Adomat H, et al. (2010) Effect of noncompetitive proteasome inhibition on bortezomib resistance. J Natl Cancer Inst 102, 1069-82. PubMed
  6. Mao X, Li X, Sprangers R, Wang X, Venugopal A, Wood T, Zhang Y, Kuntz DA, Coe E, Trudel S, et al. (2009) Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma. Leukemia 23, 585-90. PubMed
  7. Sprangers R, Li X, Mao X, Rubinstein JL, Schimmer AD & Kay LE (2008) TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors. Biochemistry 47, 6727-34. PubMed
  8. Tugarinov V, Sprangers R & Kay LE (2007) Probing side-chain dynamics in the proteasome by relaxation violated coherence transfer NMR spectroscopy. J Am Chem Soc 129, 1743-50. PubMed
  9. Sprangers R, Velyvis A & Kay LE (2007) Solution NMR of supramolecular complexes: providing new insights into function. Nat Methods 4, 697-703. PubMed
  10. Sprangers R & Kay LE (2007) Quantitative dynamics and binding studies of the 20S proteasome by NMR. Nature 445, 618-22. PubMed
  11. Sprangers R & Kay LE (2007) Probing supramolecular structure from measurement of methyl (1)H-(13)C residual dipolar couplings. J Am Chem Soc 129, 12668-9. PubMed
  12. Thibault G, Yudin J, Wong P, Tsitrin V, Sprangers R, Zhao R & Houry WA (2006) Specificity in substrate and cofactor recognition by the N-terminal domain of the chaperone ClpX. Proc Natl Acad Sci U S A 103, 17724-9. PubMed
  13. Sprangers R, Gribun A, Hwang PM, Houry WA & Kay LE (2005) Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release. Proc Natl Acad Sci U S A 102, 16678-83. PubMed
  14. Markwick PR, Sprangers R & Sattler M (2005) Local structure and anisotropic backbone dynamics from cross-correlated NMR relaxation in proteins. Angew Chem Int Ed Engl 44, 3232-7. PubMed
  15. Gribun A, Kimber MS, Ching R, Sprangers R, Fiebig KM & Houry WA (2005) The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation. J Biol Chem 280, 16185-96. PubMed
  16. Tugarinov V, Sprangers R & Kay LE (2004) Line narrowing in methyl-TROSY using zero-quantum 1H-13C NMR spectroscopy. J Am Chem Soc 126, 4921-5. PubMed
  17. Sprangers R, Selenko P, Sattler M, Sinning I & Groves MR (2003) Definition of domain boundaries and crystallization of the SMN Tudor domain. Acta Crystallogr D Biol Crystallogr 59, 366-8. PubMed
  18. Sprangers R, Groves MR, Sinning I & Sattler M (2003) High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues. J Mol Biol 327, 507-20. PubMed
  19. Selenko P, Gregorovic G, Sprangers R, Stier G, Rhani Z, Kramer A & Sattler M (2003) Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP. Mol Cell 11, 965-76. PubMed
  20. Markwick PR, Sprangers R & Sattler M (2003) Dynamic effects on j-couplings across hydrogen bonds in proteins. J Am Chem Soc 125, 644-5. PubMed
  21. Selenko P, Sprangers R, Stier G, Buhler D, Fischer U & Sattler M (2001) SMN tudor domain structure and its interaction with the Sm proteins. Nat Struct Biol 8, 27-31. PubMed
  22. Liu Z, Luyten I, Bottomley MJ, Messias AC, Houngninou-Molango S, Sprangers R, Zanier K, Kramer A & Sattler M (2001) Structural basis for recognition of the intron branch site RNA by splicing factor 1. Science 294, 1098-102. PubMed
  23. Sprangers R, Bottomley MJ, Linge JP, Schultz J, Nilges M & Sattler M (2000) Refinement of the protein backbone angle psi in NMR structure calculations. J Biomol NMR 16, 47-58. PubMed
  24. Eijkelenboom AP, Sprangers R, Hard K, Puras Lutzke RA, Plasterk RH, Boelens R & Kaptein R (1999) Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase. Proteins 36, 556-64. PubMed