Project Leader: Murray Coles | Department: Protein Evolution - Lupas
NMR spectroscopy is a powerful tool for examining the structure, dynamics and interactions of biological macromolecules in solution. The NMR spectroscopy group is part of the wider structural biology platform within the Department of Protein Evolution, and is involved in several projects investigating protein structure and function. Several projects study the evolution of complex protein folds from simpler peptide units.
CELLULAR PROTEIN FOLDING AND UNFOLDING: CHAPERONINS AND AAA ATPASES
Project Leader: Jörg Martin | Department: Protein Evolution - Lupas
Folding and unfolding of proteins in the cell is mediated by complex macromolecular machines. We investigate and compare properties of the ring-shaped bacterial GroEL/GroES chaperonin system and archaeal thermosomes, and analyse mechanistic properties of hexameric AAA ATPases.
STRUCTURE FUNCTION RELATIONSHIP
Project Leader: Steffen Schmidt | Department: Biochemistry - Izaurralde
We are interested in the effect of mutations on the function of a protein and the implication of this on diseases and population genetics.
METHODS IN PROTEIN NMR
Project Leader: Vincent Truffault | Department: Biochemistry - Izaurralde
High resolution structure determination of proteins in solution using nuclear magnetic resonance (NMR) spectroscopy crucially depends on continuous improvement of the quality of the NMR experiments. Our new NMR pulse sequences are optimized to provide artifact-free structural information.
RETROTRANSPOSITION AND REGULATORY RNAs
Project Leader: Oliver Weichenrieder | Department: Biochemistry - Izaurralde
We study the molecular basis of cellular processes that are mediated by RNA. Our focus is on molecular parasites in the human genome (LINE-1 and Alu retrotransposons) and on the regulation of mRNA degradation. We use x-ray crystallography together with biochemical approaches and cell-based assays.
LOCALIZATION OF RNA DURING DROSOPHILA OOGENESIS
Project Leader: Uwe Irion | Department: Genetics - Nüsslein-Volhard
Cellular asymmetries are very often based on the differential localization of RNA molecules. We use a combination of genetic, biochemical and cell biological methods to study the mechanism of RNA localization during oogenesis in the fruit fly. Localization of RNA within the egg cell is essential for later development of anterior structures – head and thorax - in the embryo.
NEURAL DEVELOPMENT AND WIRING
Project Leader: Christian Söllner | Department: Genetics - Nüsslein-Volhard
Extracellular protein-protein interactions are centrally involved in the initiation of cell-cell communication events required for proper nervous system wiring. The identification of such neural cell surface receptor-ligand pairs and their functional validation is the main focus of our research.
GENETICS IN PARASITIC NEMATODES
Project Leader: Adrian Streit | Department: Evolutionary Biology - Sommer
We combine molecular and genetic approaches to study life history switches and reproductive strategies in parasitic nematodes of the genera Strongyloides and Onchocerca.
Project Leader: Matthias Herrmann | Department: Evolutionary Biology - Sommer
Nematode biology, phylogeny and ecology: Being convinced that environments shape genomes we hope that the study of ecology, behaviour, interactions and relationships of nematodes in nature will explain many results molecular biology provided already but could not be explained so far.
FERTILIZATION AND EMBRYOGENESIS IN PLANTS
Project Leader: Martin Bayer | Department: Cell Biology - Jürgens
Our group is interested in signaling pathways that link fertilization with the onset of embryogenesis in plants. We are focusing on factors provided by the male gametophyte that play an important role in gamete interaction and early embryogenesis.
CONTROL OF FLOWERING TIME
Project Leader: Markus Schmid | Department: Molecular Biology - Weigel
Work in our group aims to understand the precise mechanisms that govern flowering time, in particular in response to inductive photoperiod, in the best-understood model plant, Arabidopsis thaliana. We employ a mix of molecular, genetics and genome-wide analyses.