Print page    

Publications

since the foundation of Department 2 Biochemistry in July 2006
  1. Gruner S, Peter D, Weber R, Wohlbold L, Chung MY, Weichenrieder O, Valkov E, Igreja C & Izaurralde E (2016) The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation. Mol Cell 64, 467-479. PubMed
  2. Kuzuoglu-Ozturk D, Bhandari D, Huntzinger E, Fauser M, Helms S & Izaurralde E (2016) miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning. EMBO J 35, 1186-203. PubMed
  3. Valkov E, Muthukumar S, Chang CT, Jonas S, Weichenrieder O & Izaurralde E (2016) Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation. Nat Struct Mol Biol 23, 574-9. PubMed
  4. Raisch T, Bhandari D, Sabath K, Helms S, Valkov E, Weichenrieder O & Izaurralde E (2016) Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos. EMBO J 35, 974-90. PubMed
  5. Ahl V, Keller H, Schmidt S & Weichenrieder O (2015) Retrotransposition and Crystal Structure of an Alu RNP in the Ribosome-Stalling Conformation. Mol Cell 60, 715-27. PubMed
  6. Peter D, Weber R, Kone C, Chung MY, Ebertsch L, Truffault V, Weichenrieder O, Igreja C & Izaurralde E (2015) Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Genes Dev 29, 1835-49. PubMed
  7. Izaurralde E (2015) GENE REGULATION. Breakers and blockers-miRNAs at work. Science 349, 380-2. PubMed
  8. Jonas S & Izaurralde E (2015) Towards a molecular understanding of microRNA-mediated gene silencing. Nat Rev Genet 16, 421-33. PubMed
  9. Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, Weichenrieder O & Izaurralde E (2015) Molecular Architecture of 4E-BP Translational Inhibitors Bound to eIF4E. Mol Cell 57, 1074-87. PubMed
  10. Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, et al. (2015) Fast native-SAD phasing for routine macromolecular structure determination. Nat Methods 12, 131-3. PubMed
  11. Igreja C, Peter D, Weiler C & Izaurralde E (2014) 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation. Nat Commun 5, 4790. PubMed
  12. Jonas S, Christie M, Peter D, Bhandari D, Loh B, Huntzinger E, Weichenrieder O & Izaurralde E (2014) An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. Nat Struct Mol Biol 21, 599-608. PubMed
  13. Chen Y, Boland A, Kuzuoglu-Ozturk D, Bawankar P, Loh B, Chang CT, Weichenrieder O & Izaurralde E (2014) A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Mol Cell 54, 737-50. PubMed
  14. Weichenrieder O (2014) RNA binding by Hfq and ring-forming (L)Sm proteins: a trade-off between optimal sequence readout and RNA backbone conformation. RNA Biol 11, 537-49. PubMed
  15. Chang CT, Bercovich N, Loh B, Jonas S & Izaurralde E (2014) The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Res 42, 5217-33. PubMed
  16. Bhandari D, Raisch T, Weichenrieder O, Jonas S & Izaurralde E (2014) Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev 28, 888-901. PubMed
  17. Zekri L, Kuzuoglu-Ozturk D & Izaurralde E (2013) GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J 32, 1052-65. PubMed
  18. Schneider AM, Schmidt S, Jonas S, Vollmer B, Khazina E & Weichenrieder O (2013) Structure and properties of the esterase from non-LTR retrotransposons suggest a role for lipids in retrotransposition. Nucleic Acids Res 41, 10563-72. PubMed
  19. Nishihara T, Zekri L, Braun JE & Izaurralde E (2013) miRISC recruits decapping factors to miRNA targets to enhance their degradation. Nucleic Acids Res 41, 8692-705. PubMed
  20. Loh B, Jonas S & Izaurralde E (2013) The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev 27, 2125-38. PubMed
  21. Jonas S, Weichenrieder O & Izaurralde E (2013) An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev 27, 211-25. PubMed
  22. Jonas S & Izaurralde E (2013) The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes Dev 27, 2628-41. PubMed
  23. Izaurralde E (2013) A role for eIF4AII in microRNA-mediated mRNA silencing. Nat Struct Mol Biol 20, 543-5. PubMed
  24. Huntzinger* E, Kuzuoglu-Ozturk* D, Braun JE, Eulalio A, Wohlbold L & Izaurralde E (2013) The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res 41, 978-94. (* These authors contributed equally to this work) PubMed
  25. Hentze MW & Izaurralde E (2013) Making sense of nonsense. Nat Struct Mol Biol 20, 651-3. PubMed
  26. Christie M, Boland A, Huntzinger E, Weichenrieder O & Izaurralde E (2013) Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Mol Cell 51, 360-73. PubMed
  27. Braun JE, Huntzinger E & Izaurralde E (2013) The role of GW182 proteins in miRNA-mediated gene silencing. Adv Exp Med Biol 768, 147-63. PubMed
  28. Boland* A, Chen* Y, Raisch* T, Jonas* S, Kuzuoglu-Ozturk D, Wohlbold L, Weichenrieder O & Izaurralde E (2013) Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol 20, 1289-97. (* These authors contributed equally to this work) PubMed
  29. Bawankar P, Loh B, Wohlbold L, Schmidt S & Izaurralde E (2013) NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol 10, 228-224. PubMed
  30. Sauer E, Schmidt S & Weichenrieder O (2012) Small RNA binding to the lateral surface of Hfq hexamers and structural rearrangements upon mRNA target recognition. Proc Natl Acad Sci U S A 109, 9396-401. PubMed
  31. Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2012) The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res 40, 11058-72. PubMed
  32. Kuzuoglu-Ozturk D, Huntzinger E, Schmidt S & Izaurralde E (2012) The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res 40, 5651-65. PubMed
  33. Izaurralde E (2012) Elucidating the temporal order of silencing. EMBO Rep 13, 662-3. PubMed
  34. Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E & Sprangers R (2011) The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J 31, 279-90. PubMed
  35. Braun JE, Huntzinger E & Izaurralde E (2012) A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs. Cold Spring Harb Perspect Biol 4. PubMed
  36. Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M & Izaurralde E (2012) A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol 19, 1324-31. PubMed
  37. Teplova M, Wohlbold L, Khin NW, Izaurralde E & Patel DJ (2011) Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP. Nat Struct Mol Biol 18, 990-8. PubMed
  38. Sauer E & Weichenrieder O (2011) Structural basis for RNA 3'-end recognition by Hfq. Proc Natl Acad Sci U S A 108, 13065-70. PubMed
  39. Khazina E, Truffault V, Buttner R, Schmidt S, Coles M & Weichenrieder O (2011) Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition. Nat Struct Mol Biol 18, 1006-14. PubMed
  40. Igreja C & Izaurralde E (2011) CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes Dev 25, 1955-67. PubMed
  41. Huntzinger E & Izaurralde E (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12, 99-110. PubMed
  42. Braun JE, Huntzinger E, Fauser M & Izaurralde E (2011) GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets. Mol Cell 44, 120-33. PubMed
  43. Boland A, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2011) Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A 108, 10466-71. PubMed
  44. Tritschler F, Huntzinger E & Izaurralde E (2010) Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of deja vu. Nat Rev Mol Cell Biol 11, 379-84. PubMed
  45. Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN & Izaurralde E (2010) SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev 24, 2440-50. PubMed
  46. Huntzinger E, Braun JE, Heimstadt S, Zekri L & Izaurralde E (2010) Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J 29, 4146-60. PubMed
  47. Haas G, Braun JE, Igreja C, Tritschler F, Nishihara T & Izaurralde E (2010) HPat provides a link between deadenylation and decapping in metazoa. J Cell Biol 189, 289-302. PubMed
  48. Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O & Izaurralde E (2010) The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J 29, 2368-80. PubMed
  49. Boland A, Tritschler F, Heimstädt S, Izaurralde E & Weichenrieder O (2010) Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 11, 522-7. PubMed
  50. Zekri L, Huntzinger E, Heimstadt S & Izaurralde E (2009) The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol 29, 6220-31. PubMed
  51. Wittkopp N, Huntzinger E, Weiler C, Saulière J, Schmidt S, Sonawane M & Izaurralde E (2009) Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol 29, 3517-28. PubMed
  52. Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E & Weichenrieder O (2009) DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A 106, 21591-6. PubMed
  53. Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E & Weichenrieder O (2009) Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell 33, 661-8. PubMed
  54. Lazzaretti D, Tournier I & Izaurralde E (2009) The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA 15, 1059-66. PubMed
  55. Khazina E & Weichenrieder O (2009) Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame. Proc Natl Acad Sci U S A 106, 731-6. PubMed
  56. Izaurralde E & Zamore PD (2009) Nucleus and gene expression. Curr Opin Cell Biol 21, 331-4. PubMed
  57. Izaurralde E (2009) Freedom versus constraint in protein function. Nat Rev Mol Cell Biol 10, 372. PubMed
  58. Hansen KD, Lareau LF, Blanchette M, Green RE, Meng Q, Rehwinkel J, Gallusser FL, Izaurralde E, Rio DC, Dudoit S, et al. (2009) Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet 5, e1000525. PubMed
  59. Eulalio A, Tritschler F & Izaurralde E (2009) The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA 15, 1433-42. PubMed
  60. Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E & Truffault V (2009) The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res 37, 2974-83. PubMed
  61. Eulalio A, Huntzinger E, Nishihara T, Rehwinkel J, Fauser M & Izaurralde E (2009) Deadenylation is a widespread effect of miRNA regulation. RNA 15, 21-32. PubMed
  62. Eulalio A, Helms S, Fritzsch C, Fauser M & Izaurralde E (2009) A C-terminal silencing domain in GW182 is essential for miRNA function. RNA 15, 1067-77. PubMed
  63. Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E & Truffault V (2008) Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol 28, 6695-708. PubMed
  64. Jinek M, Eulalio A, Lingel A, Helms S, Conti E & Izaurralde E (2008) The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. RNA 14, 1991-8. PubMed
  65. Huntzinger E, Kashima I, Fauser M, Saulière J & Izaurralde E (2008) SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14, 2609-17. PubMed
  66. Eulalio A, Huntzinger E & Izaurralde E (2008) Getting to the root of miRNA-mediated gene silencing. Cell 132, 9-14. PubMed
  67. Eulalio A, Huntzinger E & Izaurralde E (2008) GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol 15, 346-53. PubMed
  68. Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E & Weichenrieder O (2007) A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol 27, 8600-11. PubMed
  69. Jacobson A & Izaurralde E (2007) Nonsense-mediated mRNA decay: from yeast to metazoan. In Book Nonsense-mediated mRNA decay: from yeast to metazoan 3 edit. (Matthews M, Sonenberg N & Hershey JWB, eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
  70. Eulalio A, Rehwinkel J, Stricker M, Huntzinger E, Yang SF, Doerks T, Dorner S, Bork P, Boutros M & Izaurralde E (2007) Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev 21, 2558-70. PubMed
  71. Eulalio A, Behm-Ansmant I, Schweizer D & Izaurralde E (2007) P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol 27, 3970-81. PubMed
  72. Eulalio A, Behm-Ansmant I & Izaurralde E (2007) P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 8, 9-22. PubMed
  73. Dorner S, Eulalio A, Huntzinger E & Izaurralde E (2007) Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms. EMBO Rep 8, 723-9. PubMed
  74. Behm-Ansmant I, Kashima I, Rehwinkel J, Saulière J, Wittkopp N & Izaurralde E (2007) mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett 581, 2845-53. PubMed
  75. Behm-Ansmant I & Izaurralde E (2007) NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway. In Book NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway (Maquat LE, ed.), pp. 151-163. Landes Bioscience, Georgetown, Texas, USA.
  76. Behm-Ansmant I, Gatfield D, Rehwinkel J, Hilgers V & Izaurralde E (2007) A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J 26, 1591-601. PubMed
  77. Weigel D & Izaurralde E (2006) A tiny helper lightens the maternal load. Cell 124, 1117-8. PubMed
  78. Rehwinkel J, Raes J & Izaurralde E (2006) Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci 31, 639-46. PubMed
  79. Rehwinkel J, Natalin P, Stark A, Brennecke J, Cohen SM & Izaurralde E (2006) Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol 26, 2965-75. PubMed
  80. Glavan F, Behm-Ansmant I, Izaurralde E & Conti E (2006) Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J 25, 5117-25. PubMed
  81. Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P & Izaurralde E (2006) mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 20, 1885-98. PubMed
  82. Behm-Ansmant I & Izaurralde E (2006) Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes Dev 20, 391-8. PubMed