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Publications

  1. Gruner S, Peter D, Weber R, Wohlbold L, Chung MY, Weichenrieder O, Valkov E, Igreja C & Izaurralde E (2016) The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation. Mol Cell 64, 467-479. PubMed
  2. Valkov E, Muthukumar S, Chang CT, Jonas S, Weichenrieder O & Izaurralde E (2016) Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation. Nat Struct Mol Biol 23, 574-9. PubMed
  3. Raisch T, Bhandari D, Sabath K, Helms S, Valkov E, Weichenrieder O & Izaurralde E (2016) Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos. EMBO J 35, 974-90. PubMed
  4. Ahl V, Keller H, Schmidt S & Weichenrieder O (2015) Retrotransposition and Crystal Structure of an Alu RNP in the Ribosome-Stalling Conformation. Mol Cell 60, 715-27. PubMed
  5. Peter D, Weber R, Kone C, Chung MY, Ebertsch L, Truffault V, Weichenrieder O, Igreja C & Izaurralde E (2015) Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Genes Dev 29, 1835-49. PubMed
  6. Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, Weichenrieder O & Izaurralde E (2015) Molecular Architecture of 4E-BP Translational Inhibitors Bound to eIF4E. Mol Cell 57, 1074-87. PubMed
  7. Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, et al. (2015) Fast native-SAD phasing for routine macromolecular structure determination. Nat Methods 12, 131-3. PubMed
  8. Jonas S, Christie M, Peter D, Bhandari D, Loh B, Huntzinger E, Weichenrieder O & Izaurralde E (2014) An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. Nat Struct Mol Biol 21, 599-608. PubMed
  9. Chen Y, Boland A, Kuzuoglu-Ozturk D, Bawankar P, Loh B, Chang CT, Weichenrieder O & Izaurralde E (2014) A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing. Mol Cell 54, 737-50. PubMed
  10. Weichenrieder O (2014) RNA binding by Hfq and ring-forming (L)Sm proteins: a trade-off between optimal sequence readout and RNA backbone conformation. RNA Biol 11, 537-49. PubMed
  11. Bhandari D, Raisch T, Weichenrieder O, Jonas S & Izaurralde E (2014) Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev 28, 888-901. PubMed
  12. Schneider AM, Schmidt S, Jonas S, Vollmer B, Khazina E & Weichenrieder O (2013) Structure and properties of the esterase from non-LTR retrotransposons suggest a role for lipids in retrotransposition. Nucleic Acids Res 41, 10563-72. PubMed
  13. Jonas S, Weichenrieder O & Izaurralde E (2013) An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev 27, 211-25. PubMed
  14. Christie M, Boland A, Huntzinger E, Weichenrieder O & Izaurralde E (2013) Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Mol Cell 51, 360-73. PubMed
  15. Boland* A, Chen* Y, Raisch* T, Jonas* S, Kuzuoglu-Ozturk D, Wohlbold L, Weichenrieder O & Izaurralde E (2013) Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol 20, 1289-97. (* These authors contributed equally to this work) PubMed
  16. Sauer E, Schmidt S & Weichenrieder O (2012) Small RNA binding to the lateral surface of Hfq hexamers and structural rearrangements upon mRNA target recognition. Proc Natl Acad Sci U S A 109, 9396-401. PubMed
  17. Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2012) The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res 40, 11058-72. PubMed
  18. Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M & Izaurralde E (2012) A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol 19, 1324-31. PubMed
  19. Sauer E, Schmidt S & Weichenrieder O (2012) Small RNA binding to the lateral surface of Hfq hexamers and structural rearrangements upon mRNA target recognition. Proc Natl Acad Sci U S A 109, 9396-401. PubMed
  20. Khazina E, Truffault V, Buttner R, Schmidt S, Coles M & Weichenrieder O (2011) Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition. Nat Struct Mol Biol 18, 1006-14. PubMed
  21. Sauer E & Weichenrieder O (2011) Structural basis for RNA 3'-end recognition by Hfq. Proc Natl Acad Sci U S A 108, 13065-70. PubMed
  22. Boland A, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2011) Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A 108, 10466-71. PubMed
  23. Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O & Izaurralde E (2010) The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J 29, 2368-80. PubMed
  24. Boland A, Tritschler F, Heimstadt S, Izaurralde E & Weichenrieder O (2010) Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 11, 522-7. PubMed
  25. Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E & Weichenrieder O (2009) DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A 106, 21591-21596. PubMed
  26. Fernandez-Santiago R, Hoenig S, Lichtner P, Sperfeld AD, Sharma M, Berg D, Weichenrieder O, Illig T, Eger K, Meyer T, et al. (2009) Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. J Neurol 256, 1337-1342. PubMed
  27. Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E & Truffault V (2009) The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res 37, 2974-83. PubMed
  28. Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E & Weichenrieder O (2009) Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell 33, 661-8. PubMed
  29. Khazina E & Weichenrieder O (2009) Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame. Proc Natl Acad Sci U S A 106, 731-6. PubMed
  30. Bennett EA, Keller H, Mills RE, Schmidt S, Moran JV, Weichenrieder O & Devine SE (2008) Active Alu retrotransposons in the human genome. Genome Res 18, 1875-83. PubMed
  31. Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E & Truffault V (2008) Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol 28, 6695-708. PubMed
  32. Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E & Weichenrieder O (2007) A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol 27, 8600-11. PubMed