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Steffen Schmidt

Position: Project Leader
Unit: Izaurralde Schmidt
Phone: 1357
Picture of Schmidt, Steffen



  • PhD 2003 Bioinformatics, EMBL Heidelberg / University of Heidelberg, Germany
  • 2003-2005 Postdoctoral fellow at Division of Genetics, Brigham and Women's Hospital / Harvard Medical School, Boston, USA
  • since 2006 Project leader at the MPI for Developmental Biology, Dept of Biochemistry, Tübingen, Germany

Ahl V, Keller H, Schmidt S & Weichenrieder O (2015) Retrotransposition and Crystal Structure of an Alu RNP in the Ribosome-Stalling Conformation. Mol Cell 60, 715-27. PubMed


Randel M, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G (2015) Inter-individual stereotypy of the Platynereis larval visual connectome. eLife. PubMed


Farías-Rico JA, Schmidt S & Höcker B (2014) Evolutionary relationship of two ancient protein superfolds. Nat Chem Biol 10(9), 710-5. PubMed


Schneider AM, Schmidt S, Jonas S, Vollmer B, Khazina E & Weichenrieder O (2013) Structure and properties of the esterase from non-LTR retrotransposons suggest a role for lipids in retrotransposition. Nucleic Acids Res 41, 10563-72. PubMed


Bawankar P, Loh B, Wohlbold L, Schmidt S & Izaurralde E (2013) NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol 10, 228-244. PubMed


Sauer E, Schmidt S & Weichenrieder O (2012) Small RNA binding to the lateral surface of Hfq hexamers and structural rearrangements upon mRNA target recognition. Proc Natl Acad Sci U S A 109, 9396-401. PubMed


Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2012) The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res. PubMed


Kuzuoglu-Ozturk D, Huntzinger E, Schmidt S & Izaurralde E (2012) The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res 40, 5651-65. PubMed


Khazina E, Truffault V, Buttner R, Schmidt S, Coles M & Weichenrieder O (2011) Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition. Nat Struct Mol Biol 18, 1006-14. PubMed


Boland A, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2011) Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A 108, 10466-71. PubMed


Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS & Sunyaev SR (2010) A method and server for predicting damaging missense mutations. Nat Methods 7, 248-9. PubMed


Wittkopp N, Huntzinger E, Weiler C, Sauliere J, Schmidt S, Sonawane M & Izaurralde E (2009) Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol. PubMed


Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E & Truffault V (2008) Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol 28, 6695-708. PubMed


Schmidt S, Gerasimova A, Kondrashov FA, Adzhubei IA, Kondrashov AS & Sunyaev S (2008) Hypermutable non-synonymous sites are under stronger negative selection. PLoS Genet 4, e1000281. PubMed


Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R, et al. (2008) Proportionally more deleterious genetic variation in European than in African populations. Nature 451, 994-7. PubMed


Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, et al. (2008) Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genet 4, e1000083. PubMed


Bennett EA, Keller H, Mills RE, Schmidt S, Moran JV, Weichenrieder O & Devine SE (2008) Active Alu retrotransposons in the human genome. Genome Res 18, 1875-83. PubMed


Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E & Weichenrieder O (2007) A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol 27, 8600-11. PubMed


Spirin V, Schmidt S, Pertsemlidis A, Cooper RS, Cohen JC & Sunyaev SR (2007) Common Single-Nucleotide Polymorphisms Act in Concert to Affect Plasma Levels of High-Density Lipoprotein Cholesterol. Am J Hum Genet 81. PubMed


Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, et al. (2007) Medical sequencing at the extremes of human body mass. Am J Hum Genet 80, 779-91. PubMed


Savas S, Schmidt S, Jarjanazi H & Ozcelik H (2006) Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations. Hum Genomics 2, 287-96. PubMed


Sax U & Schmidt S (2005) Integration of genomic data in Electronic Health Records--opportunities and dilemmas. Methods Inf Med 44, 546-50. PubMed


Kryukov GV, Schmidt S & Sunyaev S (2005) Small fitness effect of mutations in highly conserved non-coding regions. Hum Mol Genet 14, 2221-9. PubMed


Asthana S, Schmidt S & Sunyaev S (2005) A limited role for balancing selection. Trends Genet 21, 30-2. PubMed


Letunic I, Copley RR, Schmidt S, Ciccarelli FD, Doerks T, Schultz J, Ponting CP & Bork P (2004) SMART 4.0: towards genomic data integration. Nucleic Acids Res 32, D142-4. PubMed


Düßner M, Lampidis R, Schmidt S, Seipel D & Dandekar T (2004) Integration of Data in Pathogenomics: Three Layers of cellular complexity and an XML-based Framework. J Integrative Bioinformatics. Link


von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P & Snel B (2003) STRING: a database of predicted functional associations between proteins. Nucleic Acids Res 31, 258-61. PubMed


Schmidt S, Sunyaev S, Bork P & Dandekar T (2003) Metabolites: a helping hand for pathway evolution? Trends Biochem Sci 28, 336-41. PubMed


Morett E, Korbel JO, Rajan E, Saab-Rincon G, Olvera L, Olvera M, Schmidt S, Snel B & Bork P (2003) Systematic discovery of analogous enzymes in thiamin biosynthesis. Nat Biotechnol 21, 790-5. PubMed


Schmidt S & Dandekar T (2002) Metabolic Pathways. In Book Metabolic Pathways (Collado-Vides J & Hofestädt R, eds.), pp. 251-272. MIT Press, Cambridge, Massachusetts; London, England.


Schmidt S, Bork P & Dandekar T (2002) A versatile structural domain analysis server using profile weight matrices. J Chem Inf Comput Sci 42, 405-7. PubMed


Höcker B, Schmidt S & Sterner R (2002) A common evolutionary origin of two elementary enzyme folds. FEBS Lett 510, 133-5. PubMed


Henn-Sax M, Thoma R, Schmidt S, Hennig M, Kirschner K & Sterner R (2002) Two (βα)8-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates. Biochemistry 41, 12032-42. PubMed


Dandekar T, Snel B, Schmidt S, Lathe W, Sunyaev S, Huynen M & Bork P (2002) Comparative genome analysis of the Mollicutes. In Book Comparative genome analysis of the Mollicutes (Razin S & Herrmann R, eds.), pp. 254-278. Kluwer Academic Plenum Publishers, Dordrecht, Netherlands.


Dandekar T, Du F, Schirmer RH & Schmidt S (2001) Medical target prediction from genome sequence: combining different sequence analysis algorithms with expert knowledge and input from artificial intelligence approaches. Comput Chem 26, 15-21. PubMed


Dandekar T*, Du F & Schmidt S* (2000) AISB 2000, Birningham, UK.

*equal contribution