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Gáspár Jékely

Position: Research Group Leader
Unit: Jékely
Phone: +49 7071 601 1310
Picture of Jékely, Gáspár



■ since 2007 Group leader at MPI for Developmental Biology, Germany

■ 2004-2007 Postdoctoral fellow at EMBL, Heidelberg, Germany
■ 2003-2004 Junior fellow at Collegium Budapest, Institute for Advanced Study, Budapest, Hungary
■ 2000-2002 Postdoctoral fellow at EMBL, Heidelberg, Germany
■ PhD 1999 Genetics, Eötvös Loránd University, Budapest, Hungary


Honours

John Kendrew Award 2012

ERC Starting Grant 2010

FEBS Long Term Postdoctoral Fellowship, 2004-2006

■ EMBO Long Term Fellowship, 2000-2002

■ EMBO science writing prize 2002

■ Young Researchers’ Prize of the Hungarian Academy of Sciences, 2000

■ Qualitas Biologica Hungarica 1999



Elizabeth A Williams, Csaba Verasztó, Sanja Jasek, Markus Conzelmann, Réza Shahidi, Philipp Bauknecht, Gáspár Jékely. Synaptic and peptidergic connectome of a neurosecretory centre in the annelid brain. Opens external link in new windowbioRxiv 115204; doi: https://doi.org/10.1101/115204

 

Csaba Verasztó, Nobuo Ueda, Luis A Bezares-Calderón, Aurora Panzera, Elizabeth A Williams, Réza Shahidi, Gáspár Jékely. Ciliomotor circuitry underlying whole-body coordination of ciliary activity in the Platynereis larva. Opens external link in new windoweLife 108035; doi: https://doi.org/10.1101/108035

 

Bauknecht P, Jékely G. Ancient coexistence of norepinephrine, tyramine, and octopamine signaling in bilaterians. Opens external link in new windowBMC Biol. 2017 Jan 30;15(1):6. doi: 10.1186/s12915-016-0341-7.

Bosch TC, Klimovich A, Domazet-Lošo T, Gründer S, Holstein TW, Jékely G, Miller DJ, Murillo-Rincon AP, Rentzsch F, Richards GS, Schröder K, Technau U, Yuste R. Back to the Basics: Cnidarians Start to Fire. Opens external link in new windowTrends Neurosci. 2017 Feb;40(2):92-105. doi: 10.1016/j.tins.2016.11.005.

 

Bezares-Calderón LA, Jékely G. Think small. Opens external link in new windowElife. 2016 Dec 6;5. pii: e22497. doi: 10.7554/eLife.22497.

 

Williams EA, Jékely G. Towards a systems-level understanding of development in the marine annelid Platynereis dumerilii. Opens external link in new windowCurr Opin Genet Dev. 2016 Aug;39:175-181. doi: 10.1016/j.gde.2016.07.005.

 

Shahidi R, Williams E, Conzelmann M, Asadulina A, Veraszto C, Jasek S, Bezares-Calderon LA, Jekely G. siGOLD: a Serial Multiplex Immunogold Labeling Method for Identifying Peptidergic Neurons in Connectomes. Opens external link in new windoweLife, 2015;10.7554/eLife.11147

 

Hanswillemenke A, Kuzdere T, Vogel P, Jékely G, Stafforst T. Site-directed RNA editing in vivo can be triggered by the light-driven assembly of an artificial riboprotein. Opens external link in new windowJ. Am. Chem. Soc. 2015 Nov 24;DOI:10.1021/jacs.5b10216.

 

Randel N, Jékely G. Phototaxis and the origin of visual eyes. Opens external link in new windowPhilos Trans R Soc Lond B Biol Sci, 2015 Nov 23;DOI: 10.1098/rstb.2015.0042.

 

Jékely G, Keijzer F, Godfrey Smith P. An Option Space for Early Neural Evolution. Philos Trans R Soc Lond B Biol Sci, 2015 Dec 19;370(1684).


Gühmann M, Jia H, Randel N, Verasztó C, Bezares-Calderón LA, Michiels NK, Yokoyama S, Jékely G. Spectral Tuning of Phototaxis by a Go-Opsin in the Rhabdomeric Eyes of Platynereis. Opens external link in new windowCurr Biol. 2015;25(17):2265-71.

 

Asadulina A, Conzelmann M, Williams EA, Panzera A, Jékely G. Object-based representation and analysis of light and electron microscopic volume data using Blender. Opens external link in new windowBMC Bioinformatics, 2015;16:229.

 

Bauknecht P, Jékely G. Large-scale combinatorial deorphanization of Platynereis neuropeptide GPCRs. Opens external link in new windowCell Reports, July 16, 2015.

 

Randel N, Shahidi R, Verasztó C, Bezares-Calderón LA, Schmidt S, Jékely G. Inter-individual stereotypy of the Platynereis larval visual connectome. Opens external link in new windowElife, 2015 Jun 10;4:e08069.

 

Jékely G, Jordi Paps J, Nielsen C. The phylogenetic position of ctenophores and the origin(s) of nervous systems. Opens external link in new windowEvoDevo, 2015, 6:1  doi:10.1186/2041-9139-6-1

 

Williams EA, Conzelmann M, Jékely G. Myoinhibitory peptide regulates feeding in the marine annelid PlatynereisOpens external link in new windowFrontiers in Zoology, 2015, 12:1  doi:10.1186/s12983-014-0093-6

 

Jékely G. Origin and evolution of the self-organizing cytoskeleton in the network of eukaryotic organelles. Opens external link in new windowCold Spring Harb Perspect Biol. 2014 Sep 2;6(9):a016030.

 

Neuronal connectome of a sensory-motor circuit for visual navigation. Randel N, Asadulina A, Bezares-Calderón LA, Verasztó C, Williams EA, Conzelmann M, Shahidi R, Jékely G. Opens external link in new windowElife, 2014 May 27:e02730.

 

The neuropeptide complement of the marine annelid Platynereis dumerilii. Conzelmann M, Williams EA, Krug K, Franz-Wachtel M, Macek B, Jékely G. Opens external link in new windowBMC Genomics, 2013 Dec 20;14(1):906.

 

Doumpas N, Jékely G, Teleman AA. Wnt6 is required for maxillary palp formation in DrosophilaBMC Biology, 2013 Oct 3;11(1):104.

 

Lapraz F, Rawlinson K, Girstmair J, Tomiczek B, Berger J, Jékely G, Telford M, Egger B. Put a tiger in your tank: the polyclad flatworm Maritigrella crozieri as a model for evodevo. Opens external link in new windowEvoDevo, 2013 Oct 9;4(1):29.

 

Randel N, Bezares-Calderón LA, Gühmann M, Shahidi R, Jékely G. Expression dynamics and protein localization of rhabdomeric opsins in Platynereis larvae. Opens external link in new windowIntegr Comp Biol. 2013 Jul;53(1):7-16

 

Jékely G. Global view of the evolution and diversity of metazoan neuropeptide signaling. Opens external link in new windowProc Natl Acad Sci U S A. 2013 May 21;110(21):8702-7.

 

Conzelmann M, Williams EA, Tunaru S, Randel N, Shahidi R, Asadulina A, Berger J, Offermanns S, Jékely G. Conserved MIP receptor-ligand pair regulates Platynereis larval settlement. Opens external link in new windowProc Natl Acad Sci U S A. 2013;110(20):8224-9.

Holder T, Basquin C, Ebert J, Randel N, Jollivet D, Conti E, Jékely G, Bono F. Deep transcriptome-sequencing and proteome analysis of the hydrothermal vent annelid Alvinella pompejana identifies the CvP-bias as a robust measure of eukaryotic thermostability. Biology Direct, 2013, 8:2.

Asadulina A, Panzera A, Verasztó Cs, Liebig C, Jékely G. Whole-body gene expression pattern registration in Platynereis larvae. EvoDevo, 2012, 3:27.

Conzelmann M and Jékely G. Antibodies against conserved amidated neuropeptide epitopes enrich the comparative neurobiology toolbox. EvoDevo, 2012, 3:23.

 

Conzelmann M, Offenburger SL, Asadulina S, Keller T, Münch TA, Jékely G. Neuropeptides regulate swimming depth of Platynereis larvae. Proc Natl Acad Sci U S A. 2011. 108(46): p. E1174-83.

 

Jékely G. Origin and early evolution of neural circuits for the control of ciliary locomotion. Proc Biol Sci. 2011. 278(1707): p. 914-22.

 

Jékely G. Evolution of phototaxis. Philos Trans R Soc Lond B Biol Sci. 2009. 364(1531):2795-808.

 

Satir P, Mitchell DR, and Jékely G. How did the cilium evolve? Curr Top Dev Biol. 2008. 85: p. 63-82.

 

Jékely G, Colombelli J, Hausen H, Guy K, Stelzer E, Nédélec F, Arendt D. Mechanism of phototaxis in marine zooplankton. Nature, 2008. 456(7220): p. 395-9.

 

Jékely G. Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell. Biol Direct, 2008. 3: p. 31.

 

Jékely G. Evolution of the Golgi complex. in The Golgi Apparatus editors: Mironov A, Pavelka M. 2008 SpringerWienNewYork

 

Arendt D, Denes A, Jékely G, Tessmar-Raible K. The evolution of nervous system centralization. Philos Trans R Soc Lond B Biol Sci, 2008. 363(1496): p. 1523-8.

 

Jékely, G. and Arendt D. Cellular resolution expression profiling using confocal etection of NBT/BCIP precipitate by reflection microscopy. Biotechniques, 2007. 42(6): p. 751-5.

 

Jékely G. Origin of phagotrophic eukaryotes as social cheaters in microbial biofilms. Biol Direct, 2007. 2: p. 3.

 

Jékely G. Origin of eukaryotic endomembranes: a critical evaluation of different model scenarios. Adv Exp Med Biol, 2007. 607: p.38-51.

 

Denes A1, Jékely G1, Steinmetz P, Raible F, Snyman H, Prud’homme B, Ferrier D, Balavoine G, Arendt D. Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria. Cell, 2007. 129(2): p. 277-88. 1Equally contributing authors

 

Jékely, G. and Arendt D. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Bioessays, 2006. 28(2): p. 191-8.

 

Jékely G. Did the last common ancestor have a biological membrane? Biol Direct, 2006. 1: p. 35.

 

Jékely G, Sung H, Luque CM,  Rørth P. Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev Cell, 2005. 9(2): p. 197-207.

 

Jékely G. Glimpsing over the event horizon: evolution of nuclear pores and envelope. Cell Cycle, 2005. 4(2): p. 297-9.

 

Fritzsch B, Piatigorsky J, Tessmar-Raible K, Jékely G, Guy K, Raible F, Wittbrodt J, Arendt D. Ancestry of Photic and Mechanic Sensation? Science, 2005. 308(5725): p. 1113-1114.

 

Farkas A, Tompa P, Schád E, Sinka R, Jékely G, Friedrich P. Autolytic activation and localization in Schneider cells (S2) of calpain B from Drosophila. Biochem J, 2004. 378(Pt 2): p. 299-305.

 

Jékely, G. and Rørth P. Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep, 2003. 4(12): p. 1163-8.

 

Jékely G. Small GTPases and the evolution of the eukaryotic cell. Bioessays, 2003. 25(11): p. 1129-38.

 

Schád E, Farkas A, Jékely G, Tompa P, Friedrich P. A novel human small subunit of calpains. Biochem J, 2002. 362(Pt 2): p. 383-8.

 

Jékely G. Evolution in a nutshell. EMBL PhD student symposium on evolution. EMBO Rep, 2002. 3(4): p. 307-11.

 

Jékely G. The human genome sequence. A triumph of chemistry: If the history of molecular biology is written in the future, the first chapter should be devoted to the chemists who did the ground work. EMBO Rep, 2002. 3(7): p. 594-5.

 

Szabo, K., G. Jékely, Rørth P. Cloning and expression of sprint, a Drosophila homologue of RIN1. Mech Dev, 2001. 101(1-2): p. 259-62.

 

Duchek P, Somogyi K, Jékely G, Beccari S, Rørth P. Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Cell, 2001. 107(1): p. 17-26.

 

Jékely G. M. Pinter, Friedrich P. Drosophila calpains. Purification of a calpain-like enzyme from fruit flies, and expression in Escherichia coli. Methods Mol Biol, 2000. 144: p. 67-74.

 

Jékely, G. and Friedrich P. The evolution of the calpain family as reflected in paralogous chromosome regions. J Mol Evol, 1999. 49(2): p. 272-81.

 

Jékely, G. and Friedrich P. Characterization of two recombinant Drosophila calpains. CALPA and a novel homolog, CALPB. J Biol Chem, 1999. 274(34): p. 23893-900.

 

Pintér M, Jékely G, Szepesi RJ, Farkas A, Theopold U, Meyer HE, Lindholm D, Nässel DR, Hultmark D, Friedrich P. TER94, a Drosophila homolog of the membrane fusion protein CDC48/p97, is accumulated in nonproliferating cells: in the reproductive organs and in the brain of the imago. Insect Biochem Mol Biol, 1998. 28(2): p. 91-8.

 

Books

Jékely G. (editor) Eukaryotic Membranes and Cytoskeleton: Origins and Evolution. 2007, Landes Bioscience.

Jékely G. The Story of Genetics, Development and Evolution: A Historical Dialogue. World Scientific Press, in press. First published in Hungarian, 2006, Bratislava: Kalligram.