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Elisa Izaurralde

Position: Director
Unit: Izaurralde
Phone: +49 7071 601 1350
Picture of Izaurralde, Elisa

  •   PhD 1990 University of Geneva, Switzerland
  • 1990-1996 Postdoctoral training at EMBL, Germany
  • 1996-1999 Research Group Leader at the University of Geneva
  • 1999-2006 Group Leader and Senior Scientist at EMBL
  • since 2006 Scientific Director at MPI for Developmental Biology, Dept of Biochemistry, Tübingen, Germany

  1. Gruner S, Peter D, Weber R, Wohlbold L, Chung MY, Weichenrieder O, Valkov E, Igreja C & Izaurralde E (2016) The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation. Mol Cell 64, 467-479. PubMed
  2. Kuzuoglu-Ozturk D, Bhandari D, Huntzinger E, Fauser M, Helms S & Izaurralde E (2016) miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning. EMBO J 35, 1186-203. PubMed
  3. Valkov E, Muthukumar S, Chang CT, Jonas S, Weichenrieder O & Izaurralde E (2016) Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation. Nat Struct Mol Biol 23, 574-9. PubMed
  4. Raisch T, Bhandari D, Sabath K, Helms S, Valkov E, Weichenrieder O & Izaurralde E (2016) Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos. EMBO J 35, 974-90. PubMed
  5. Peter D, Weber R, Kone C, Chung MY, Ebertsch L, Truffault V, Weichenrieder O, Igreja C & Izaurralde E (2015) Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Genes Dev 29, 1835-49. PubMed
  6. Izaurralde E (2015) GENE REGULATION. Breakers and blockers-miRNAs at work. Science 349, 380-2. PubMed
  7. Jonas S & Izaurralde E (2015) Towards a molecular understanding of microRNA-mediated gene silencing. Nat Rev Genet 16, 421-33. PubMed
  8. Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, Weichenrieder O & Izaurralde E (2015) Molecular Architecture of 4E-BP Translational Inhibitors Bound to eIF4E. Mol Cell 57, 1074-87. PubMed
  9. Igreja C, Peter D, Weiler C & Izaurralde E (2014) 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation. Nat Commun 5, 4790. PubMed
  10. Jonas S, Christie M, Peter D, Bhandari D, Loh B, Huntzinger E, Weichenrieder O & Izaurralde E (2014) An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. Nat Struct Mol Biol 21, 599-608. PubMed
  11. Chen Y, Boland A, Kuzuoglu-Ozturk D, Bawankar P, Loh B, Chang CT, Weichenrieder O & Izaurralde E (2014) A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing. Mol Cell 54, 737-50. PubMed
  12. Chang CT, Bercovich N, Loh B, Jonas S & Izaurralde E (2014) The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Res 42, 5217-33. PubMed
  13. Bhandari D, Raisch T, Weichenrieder O, Jonas S & Izaurralde E (2014) Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes Dev 28, 888-901. PubMed
  14. Zekri L, Kuzuoglu-Ozturk D & Izaurralde E (2013) GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J 32, 1052-65. PubMed
  15. Nishihara T, Zekri L, Braun JE & Izaurralde E (2013) miRISC recruits decapping factors to miRNA targets to enhance their degradation. Nucleic Acids Res 41, 8692-705. PubMed
  16. Loh B, Jonas S & Izaurralde E (2013) The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev 27, 2125-38. PubMed
  17. Jonas S, Weichenrieder O & Izaurralde E (2013) An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev 27, 211-25. PubMed
  18. Jonas S & Izaurralde E (2013) The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes Dev 27, 2628-41. PubMed
  19. Izaurralde E (2013) A role for eIF4AII in microRNA-mediated mRNA silencing. Nat Struct Mol Biol 20, 543-5. PubMed
  20. Huntzinger* E, Kuzuoglu-Ozturk* D, Braun JE, Eulalio A, Wohlbold L & Izaurralde E (2013) The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res 41, 978-94. (* These authors contributed equally to this work) PubMed
  21. Hentze MW & Izaurralde E (2013) Making sense of nonsense. Nat Struct Mol Biol 20, 651-3. PubMed
  22. Christie M, Boland A, Huntzinger E, Weichenrieder O & Izaurralde E (2013) Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Mol Cell 51, 360-73. PubMed
  23. Braun JE, Huntzinger E & Izaurralde E (2013) The role of GW182 proteins in miRNA-mediated gene silencing. Adv Exp Med Biol 768, 147-63. PubMed
  24. Boland* A, Chen* Y, Raisch* T, Jonas* S, Kuzuoglu-Ozturk D, Wohlbold L, Weichenrieder O & Izaurralde E (2013) Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat Struct Mol Biol 20, 1289-97. (* These authors contributed equally to this work) PubMed
  25. Bawankar P, Loh B, Wohlbold L, Schmidt S & Izaurralde E (2013) NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol 10, 228-244 PubMed
  26. Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2012) The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Res 40, 11058-72. PubMed
  27. Kuzuoglu-Ozturk D, Huntzinger E, Schmidt S & Izaurralde E (2012) The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res 40, 5651-65. PubMed
  28. Izaurralde E (2012) Elucidating the temporal order of silencing. EMBO Rep 13, 662-3. PubMed
  29. Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E & Sprangers R (2012) The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J 31, 279-90. PubMed
  30. Braun JE, Huntzinger E & Izaurralde E (2012) A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs. Cold Spring Harb Perspect Biol 4. PubMed
  31. Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M & Izaurralde E (2012) A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol 19, 1324-31. PubMed
  32. Teplova M, Wohlbold L, Khin NW, Izaurralde E & Patel DJ (2011) Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP. Nat Struct Mol Biol 18, 990-8. PubMed
  33. Igreja C & Izaurralde E (2011) CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes Dev 25, 1955-67. PubMed
  34. Huntzinger E & Izaurralde E (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12, 99-110. PubMed
  35. Braun JE, Huntzinger E, Fauser M & Izaurralde E (2011) GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets. Mol Cell 44, 120-33. PubMed
  36. Boland A, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2011) Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A 108, 10466-71. PubMed
  37. Tritschler F, Huntzinger E & Izaurralde E (2010) Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of deja vu. Nat Rev Mol Cell Biol 11, 379-84. PubMed
  38. Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN & Izaurralde E (2010) SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev 24, 2440-50. PubMed
  39. Huntzinger E, Braun JE, Heimstadt S, Zekri L & Izaurralde E (2010) Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J 29, 4146-60. PubMed
  40. Haas G, Braun JE, Igreja C, Tritschler F, Nishihara T & Izaurralde E (2010) HPat provides a link between deadenylation and decapping in metazoa. J Cell Biol 189, 289-302. PubMed
  41. Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O & Izaurralde E (2010) The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J 29, 2368-80. PubMed
  42. Boland A, Tritschler F, Heimstädt S, Izaurralde E & Weichenrieder O (2010) Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 11, 522-7. PubMed
  43. Zekri L, Huntzinger E, Heimstadt S & Izaurralde E (2009) The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol 29, 6220-31. PubMed
  44. Wittkopp N, Huntzinger E, Weiler C, Saulière J, Schmidt S, Sonawane M & Izaurralde E (2009) Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol 29, 3517-28. PubMed
  45. Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E & Weichenrieder O (2009) DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A 106, 21591-6. PubMed
  46. Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E & Weichenrieder O (2009) Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell 33, 661-8. PubMed
  47. Lazzaretti D, Tournier I & Izaurralde E (2009) The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA 15, 1059-66. PubMed
  48. Izaurralde E & Zamore PD (2009) Nucleus and gene expression. Curr Opin Cell Biol 21, 331-4. PubMed
  49. Izaurralde E (2009) Freedom versus constraint in protein function. Nat Rev Mol Cell Biol 10, 372. PubMed
  50. Hansen KD, Lareau LF, Blanchette M, Green RE, Meng Q, Rehwinkel J, Gallusser FL, Izaurralde E, Rio DC, Dudoit S, et al. (2009) Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet 5, e1000525. PubMed
  51. Eulalio A, Tritschler F & Izaurralde E (2009) The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA 15, 1433-42. PubMed
  52. Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E & Truffault V (2009) The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res 37, 2974-83. PubMed
  53. Eulalio A, Huntzinger E, Nishihara T, Rehwinkel J, Fauser M & Izaurralde E (2009) Deadenylation is a widespread effect of miRNA regulation. RNA 15, 21-32. PubMed
  54. Eulalio A, Helms S, Fritzsch C, Fauser M & Izaurralde E (2009) A C-terminal silencing domain in GW182 is essential for miRNA function. RNA 15, 1067-77. PubMed
  55. Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E & Truffault V (2008) Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol 28, 6695-708. PubMed
  56. Jinek M, Eulalio A, Lingel A, Helms S, Conti E & Izaurralde E (2008) The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. RNA 14, 1991-8. PubMed
  57. Huntzinger E, Kashima I, Fauser M, Saulière J & Izaurralde E (2008) SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14, 2609-17. PubMed
  58. Eulalio A, Huntzinger E & Izaurralde E (2008) Getting to the root of miRNA-mediated gene silencing. Cell 132, 9-14. PubMed
  59. Eulalio A, Huntzinger E & Izaurralde E (2008) GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol 15, 346-53. PubMed
  60. Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E & Weichenrieder O (2007) A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol 27, 8600-11. PubMed
  61. Jacobson A & Izaurralde E (2007) Nonsense-mediated mRNA decay: from yeast to metazoan. In Book Nonsense-mediated mRNA decay: from yeast to metazoan 3 edit. (Matthews M, Sonenberg N & Hershey JWB, eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
  62. Eulalio A, Rehwinkel J, Stricker M, Huntzinger E, Yang SF, Doerks T, Dorner S, Bork P, Boutros M & Izaurralde E (2007) Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev 21, 2558-70. PubMed
  63. Eulalio A, Behm-Ansmant I, Schweizer D & Izaurralde E (2007) P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol 27, 3970-81. PubMed
  64. Eulalio A, Behm-Ansmant I & Izaurralde E (2007) P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 8, 9-22. PubMed
  65. Dorner S, Eulalio A, Huntzinger E & Izaurralde E (2007) Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms. EMBO Rep 8, 723-9. PubMed
  66. Behm-Ansmant I, Kashima I, Rehwinkel J, Saulière J, Wittkopp N & Izaurralde E (2007) mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett 581, 2845-53. PubMed
  67. Behm-Ansmant I & Izaurralde E (2007) NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway. In Book NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway (Maquat LE, ed.), pp. 151--163. Landes Bioscience, Georgetown, Texas, USA.
  68. Behm-Ansmant I, Gatfield D, Rehwinkel J, Hilgers V & Izaurralde E (2007) A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J 26, 1591-601. PubMed
  69. Weigel D & Izaurralde E (2006) A tiny helper lightens the maternal load. Cell 124, 1117-8. PubMed
  70. Rehwinkel J, Raes J & Izaurralde E (2006) Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci 31, 639-46. PubMed
  71. Rehwinkel J, Natalin P, Stark A, Brennecke J, Cohen SM & Izaurralde E (2006) Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol 26, 2965-75. PubMed
  72. Glavan F, Behm-Ansmant I, Izaurralde E & Conti E (2006) Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J 25, 5117-25. PubMed
  73. Behm-Ansmant I, Rehwinkel J & Izaurralde E (2006) MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay. Cold Spring Harb Symp Quant Biol 71, 523-30. PubMed
  74. Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P & Izaurralde E (2006) mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 20, 1885-98. PubMed
  75. Behm-Ansmant I & Izaurralde E (2006) Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes Dev 20, 391-8. PubMed
  76. Rehwinkel J, Letunic I, Raes J, Bork P & Izaurralde E (2005) Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA 11, 1530-44. PubMed
  77. Rehwinkel J, Behm-Ansmant I, Gatfield D & Izaurralde E (2005) A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA 11, 1640-7. PubMed
  78. Orban TI & Izaurralde E (2005) Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. RNA 11, 459-69. PubMed
  79. Lingel A, Simon B, Izaurralde E & Sattler M (2005) The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO Rep 6, 1149-55. PubMed
  80. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, et al. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature 434, 724-31. PubMed
  81. Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E & Conti E (2005) SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol Cell 17, 537-47. PubMed
  82. Conti E & Izaurralde E (2005) Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species. Curr Opin Cell Biol 17, 316-25. PubMed
  83. Ciccarelli FD, von Mering C, Suyama M, Harrington ED, Izaurralde E & Bork P (2005) Complex genomic rearrangements lead to novel primate gene function. Genome Res 15, 343-51. PubMed
  84. Unterholzner L & Izaurralde E (2004) SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol Cell 16, 587-96. PubMed
  85. Rehwinkel J, Herold A, Gari K, Kocher T, Rode M, Ciccarelli FL, Wilm M & Izaurralde E (2004) Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol 11, 558-66. PubMed
  86. Palacios IM, Gatfield D, St Johnston D & Izaurralde E (2004) An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature 427, 753-7. PubMed
  87. Lingel A, Simon B, Izaurralde E & Sattler M (2004) Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol 11, 576-7. PubMed
  88. Lingel A, Simon B, Izaurralde E & Sattler M (2004) NMR assignment of the Drosophila Argonaute2 PAZ domain. J Biomol NMR 29, 421-2. PubMed
  89. Lingel A & Izaurralde E (2004) RNAi: finding the elusive endonuclease. RNA 10, 1675-9. PubMed
  90. Kadlec J, Izaurralde E & Cusack S (2004) The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nat Struct Mol Biol 11, 330-7. PubMed
  91. Jinek M, Rehwinkel J, Lazarus BD, Izaurralde E, Hanover JA & Conti E (2004) The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nat Struct Mol Biol 11, 1001-7. PubMed
  92. Izaurralde E (2004) Directing mRNA export. Nat Struct Mol Biol 11, 210-2. PubMed
  93. Gatfield D & Izaurralde E (2004) Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature 429, 575-8. PubMed
  94. Forler D, Rabut G, Ciccarelli FD, Herold A, Kocher T, Niggeweg R, Bork P, Ellenberg J & Izaurralde E (2004) RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Mol Cell Biol 24, 1155-67. PubMed
  95. Bono F, Ebert J, Unterholzner L, Güttler T, Izaurralde E & Conti E (2004) Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. EMBO Rep 5, 304-10. PubMed
  96. Stutz F & Izaurralde E (2003) The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends Cell Biol 13, 319-27. PubMed
  97. Lingel A, Simon B, Izaurralde E & Sattler M (2003) Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature 426, 465-9. PubMed
  98. Herold A, Teixeira L & Izaurralde E (2003) Genome-wide analysis of nuclear mRNA export pathways in Drosophila. EMBO J 22, 2472-83. PubMed
  99. Gatfield D, Unterholzner L, Ciccarelli FD, Bork P & Izaurralde E (2003) Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J 22, 3960-70. PubMed
  100. Fribourg S, Gatfield D, Izaurralde E & Conti E (2003) A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol 10, 433-9. PubMed
  101. Forler D, Kocher T, Rode M, Gentzel M, Izaurralde E & Wilm M (2003) An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol 21, 89-92. PubMed
  102. Ciccarelli FD, Izaurralde E & Bork P (2003) The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. BMC Bioinformatics 4, 64. PubMed
  103. Izaurralde E (2002) Nuclear export of messenger RNA. Results Probl Cell Differ 35, 133-50. PubMed
  104. Izaurralde E (2002) A novel family of nuclear transport receptors mediates the export of messenger RNA to the cytoplasm. Eur J Cell Biol 81, 577-84. PubMed
  105. Izaurralde E (2002) Nuclear Export of messenger RNA. In Book Nuclear Export of messenger RNA (Weis K, ed.), pp. 133--150. Springer-Verlag.
  106. Gatfield D & Izaurralde E (2002) REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J Cell Biol 159, 579-88. PubMed
  107. Braun IC, Herold A, Rode M & Izaurralde E (2002) Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Mol Cell Biol 22, 5405-18. PubMed
  108. Rodrigues JP, Rode M, Gatfield D, Blencowe BJ, Carmo-Fonseca M & Izaurralde E (2001) REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proc Natl Acad Sci U S A 98, 1030-5. PubMed
  109. Le Hir H, Gatfield D, Izaurralde E & Moore MJ (2001) The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J 20, 4987-97. PubMed
  110. Le Hir H, Gatfield D, Braun IC, Forler D & Izaurralde E (2001) The protein Mago provides a link between splicing and mRNA localization. EMBO Rep 2, 1119-24. PubMed
  111. Koffa MD, Clements JB, Izaurralde E, Wadd S, Wilson SA, Mattaj IW & Kuersten S (2001) Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J 20, 5769-78. PubMed
  112. Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P & Froyen G (2001) NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Curr Biol 11, 1381-91. PubMed
  113. Izaurralde E (2001) Friedrich Miescher Prize awardee lecture review. A conserved family of nuclear export receptors mediates the exit of messenger RNA to the cytoplasm. Cell Mol Life Sci 58, 1105-12. PubMed
  114. Hir HL, Gatfield D, Izaurralde E & Moore MJ (2001) The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J 20, 4987--97. PubMed
  115. Herold A, Klymenko T & Izaurralde E (2001) NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila. RNA 7, 1768-80. PubMed
  116. Gatfield D, Le Hir H, Schmitt C, Braun IC, Kocher T, Wilm M & Izaurralde E (2001) The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila. Curr Biol 11, 1716-21. PubMed
  117. Fribourg S, Braun IC, Izaurralde E & Conti E (2001) Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. Mol Cell 8, 645-56. PubMed
  118. Conti E & Izaurralde E (2001) Nucleocytoplasmic transport enters the atomic age. Curr Opin Cell Biol 13, 310-9. PubMed
  119. Braun IC, Herold A, Rode M, Conti E & Izaurralde E (2001) Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. J Biol Chem 276, 20536-43. PubMed
  120. von Kobbe C, van Deursen JM, Rodrigues JP, Sitterlin D, Bachi A, Wu X, Wilm M, Carmo-Fonseca M & Izaurralde E (2000) Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. Mol Cell 6, 1243-52. PubMed
  121. Suyama M, Doerks T, Braun IC, Sattler M, Izaurralde E & Bork P (2000) Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins. EMBO Rep 1, 53-8. PubMed
  122. Stutz F, Bachi A, Doerks T, Braun IC, Seraphin B, Wilm M, Bork P & Izaurralde E (2000) REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA 6, 638-50. PubMed
  123. Paca RE, Ogert RA, Hibbert CS, Izaurralde E & Beemon KL (2000) Rous sarcoma virus DR posttranscriptional elements use a novel RNA export pathway. J Virol 74, 9507-14. PubMed
  124. Liker E, Fernandez E, Izaurralde E & Conti E (2000) The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain. EMBO J 19, 5587-98. PubMed
  125. Le Hir H, Izaurralde E, Maquat LE & Moore MJ (2000) The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J 19, 6860-9. PubMed
  126. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P & Izaurralde E (2000) TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Mol Cell Biol 20, 8996-9008. PubMed
  127. Hentze MW, Izaurralde E & Seraphin B (2000) A new era for the RNA world. Conference: RNA 2000. EMBO Rep 1, 394-8. PubMed
  128. Bachi A, Braun IC, Rodrigues JP, Pante N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Görlich D, Carmo-Fonseca M, et al. (2000) The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA 6, 136-58. PubMed
  129. Schmitt C, von Kobbe C, Bachi A, Pante N, Rodrigues JP, Boscheron C, Rigaut G, Wilm M, Seraphin B, Carmo-Fonseca M, et al. (1999) Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. EMBO J 18, 4332-47. PubMed
  130. Paraskeva E, Izaurralde E, Bischoff FR, Huber J, Kutay U, Hartmann E, Luhrmann R & Görlich D (1999) CRM1-mediated recycling of snurportin 1 to the cytoplasm. J Cell Biol 145, 255-64. PubMed
  131. Lipowsky G, Bischoff FR, Izaurralde E, Kutay U, Schafer S, Gross HJ, Beier H & Görlich D (1999) Coordination of tRNA nuclear export with processing of tRNA. RNA 5, 539-49. PubMed
  132. Izaurralde E, Kann M, Pante N, Sodeik B & Hohn T (1999) Viruses, microorganisms and scientists meet the nuclear pore. Leysin, VD, Switzerland, February 26-March 1, 1998. EMBO J 18, 289-96. PubMed
  133. Braun IC, Rohrbach E, Schmitt C & Izaurralde E (1999) TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. EMBO J 18, 1953-65. PubMed
  134. Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E & Görlich D (1998) Identification of a tRNA-specific nuclear export receptor. Mol Cell 1, 359-69. PubMed
  135. Izaurralde E & Adam S (1998) Transport of macromolecules between the nucleus and the cytoplasm. RNA 4, 351-64. PubMed
  136. Gruter P, Tabernero C, von Kobbe C, Schmitt C, Saavedra C, Bachi A, Wilm M, Felber BK & Izaurralde E (1998) TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol Cell 1, 649-59. PubMed
  137. Saavedra C, Felber B & Izaurralde E (1997) The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export. Curr Biol 7, 619-28. PubMed
  138. Pante N, Jarmolowski A, Izaurralde E, Sauder U, Baschong W & Mattaj IW (1997) Visualizing nuclear export of different classes of RNA by electron microscopy. RNA 3, 498-513. PubMed
  139. Palacios I & Izaurralde E (1997) An immersion in nucleocytoplasmic transport at the Garda lake. Trends Cell Biol 7, 81-3. PubMed
  140. Lewis JD & Izaurralde E (1997) The role of the cap structure in RNA processing and nuclear export. Eur J Biochem 247, 461-9. PubMed
  141. Kutay U, Izaurralde E, Bischoff FR, Mattaj IW & Görlich D (1997) Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J 16, 1153-63. PubMed
  142. Izaurralde E, Kutay U, von Kobbe C, Mattaj IW & Görlich D (1997) The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J 16, 6535-47. PubMed
  143. Izaurralde E, Jarmolowski A, Beisel C, Mattaj IW, Dreyfuss G & Fischer U (1997) A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol 137, 27-35. PubMed
  144. Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S & Izaurralde E (1997) A novel class of RanGTP binding proteins. J Cell Biol 138, 65-80. PubMed
  145. Gamberi C, Izaurralde E, Beisel C & Mattaj IW (1997) Interaction between the human nuclear cap-binding protein complex and hnRNP F. Mol Cell Biol 17, 2587-97. PubMed
  146. Flaherty SM, Fortes P, Izaurralde E, Mattaj IW & Gilmartin GM (1997) Participation of the nuclear cap binding complex in pre-mRNA 3' processing. Proc Natl Acad Sci U S A 94, 11893-8. PubMed
  147. Visa N, Izaurralde E, Ferreira J, Daneholt B & Mattaj IW (1996) A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export. J Cell Biol 133, 5-14. PubMed
  148. Stutz F, Izaurralde E, Mattaj IW & Rosbash M (1996) A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Mol Cell Biol 16, 7144-50. PubMed
  149. Lewis JD, Izaurralde E, Jarmolowski A, McGuigan C & Mattaj IW (1996) A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site. Genes Dev 10, 1683-98. PubMed
  150. Görlich D, Kraft R, Kostka S, Vogel F, Hartmann E, Laskey RA, Mattaj IW & Izaurralde E (1996) Importin provides a link between nuclear protein import and U snRNA export. Cell 87, 21-32. PubMed
  151. Izaurralde E, McGuigan C & Mattaj IW (1995) Nuclear localization of a cap-binding protein complex. Cold Spring Harb Symp Quant Biol 60, 669-75. PubMed
  152. Izaurralde E & Mattaj IW (1995) RNA export. Cell 81, 153-9. PubMed
  153. Izaurralde E, Lewis J, Gamberi C, Jarmolowski A, McGuigan C & Mattaj IW (1995) A cap-binding protein complex mediating U snRNA export. Nature 376, 709-12. PubMed
  154. Jarmolowski A, Boelens WC, Izaurralde E & Mattaj IW (1994) Nuclear export of different classes of RNA is mediated by specific factors. J Cell Biol 124, 627-35. PubMed
  155. Izaurralde E, Lewis J, McGuigan C, Jankowska M, Darzynkiewicz E & Mattaj IW (1994) A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell 78, 657-68. PubMed
  156. Mattaj IW, Boelens W, Izaurralde E, Jarmolowski A & Kambach C (1993) Nucleocytoplasmic transport and snRNP assembly. Mol Biol Rep 18, 79-83. PubMed
  157. Izaurralde E, Stepinski J, Darzynkiewicz E & Mattaj IW (1992) A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs. J Cell Biol 118, 1287-95. PubMed
  158. Izaurralde E & Mattaj IW (1992) Transport of RNA between nucleus and cytoplasm. Semin Cell Biol 3, 279-88. PubMed
  159. Raska I, Michel LS, Jarnik M, Dundr M, Fakan S, Gasser S, Gassmann M, Hübscher U, Izaurralde E, Martinez E, et al. (1991) Ultrastructural cryoimmunocytochemistry is a convenient tool for the study of DNA replication in cultured cells. J Electron Microsc Tech 18, 91-105. PubMed
  160. Fankhauser C, Izaurralde E, Adachi Y, Wingfield P & Laemmli UK (1991) Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element. Mol Cell Biol 11, 2567-75. PubMed
  161. Manen D, Izaurralde E, Churchward G & Caro L (1989) Transcription events in the origin of replication of plasmid pSC101. J Bacteriol 171, 6482-92. PubMed
  162. Kas E, Izaurralde E & Laemmli UK (1989) Specific inhibition of DNA binding to nuclear scaffolds and histone H1 by distamycin. The role of oligo(dA).oligo(dT) tracts. J Mol Biol 210, 587-99. PubMed
  163. Izaurralde E, Kas E & Laemmli UK (1989) Highly preferential nucleation of histone H1 assembly on scaffold-associated regions. J Mol Biol 210, 573-85. PubMed
  164. Izaurralde E, Mirkovitch J & Laemmli UK (1988) Interaction of DNA with nuclear scaffolds in vitro. J Mol Biol 200, 111-25. PubMed