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Heike Budde

Position: Research Scientist
Unit: Izaurralde
Phone: +49 7071 601 1370
Picture of Budde, Heike



  • 2003 PhD at the University of Braunschweig, Germany
  • 2004-2005 Postdoctoral scientist at the Relia Tech GmbH, Tübingen, Germany
  • since 2008 Scientist at the MPI for Developmental Biology, Dept of Biochemistry, Tübingen, Germany

Castro H., Sousa C., Novais M., Santos M., Budde H., Cordeiro-da-Silva A., Flohé L., Tomás A.M. (2004) Two linked genes of Leishmania infantum encode tryparedoxins localised to cytosol and mitochondrion. Mol. Biochem. Parasitol 136(2) 137-147. PubMed

Trujillo M., Budde H., Pineyro M.D., Stehr M., Robello C., Flohe L. and Radi R. (2004) Trypanosoma brucei and trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols. J Biol Chem 279(33) 34175-34182.PubMed

Jäger T., Budde H., Flohé L., Menge U., Singh M., Trujillo M., and Radi R. (2004) Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosisArchives of Biochemistry and Biophysics (ABB) 423(1) 182-191. PubMed

Krumme D., Budde H., Hecht H.-J., Menge U., Ohlenschläger O., Roß A., Wissing J., Wray V. and Flohé L. (2003) NMR studies of the interaction of tryparedoxin with redox-inactive substrate homologues. Biochemistry 42 14720-14728. PubMed

Budde H., Flohé L., Hofmann B. and Nimtz M. (2003) Verification of the interaction of a tryparedoxin peroxidase with tryparedoxin by ESI-MS/MS. Biol Chem 384 1305-1309. PubMed

Flohé L., Budde H. and Hofmann B. (2003) Peroxiredoxins in antioxidant defense and regulation. Biofactors 19(1-2)  3-10; Review. PubMed

Budde H., Flohé L., Hecht H.-J., Hofmann B., Stehr M., Wissing J. and Lünsdorf H. (2003) Kinetics and redox-sensitive oligomerisation reveal negative cooperativity in tryparedoxin peroxidase of T. brucei bruceiBiol Chem 384 619-633. PubMed

Castro H., Budde H. , Flohé L., Hofmann B., Lünsdorf H., Wissing J., Tomás A. (2002) Specificity and kinetics of a mitochondrial peroxiredoxin of Leishmania infantumFree Rad Biol & Med 33(11) 1563-1574. PubMed

Adlercreutz D., Budde H. and Wehtje E. (2002) Synthesis of Phosphatidylcholine with defined fatty acid in the sn-1 position by lipase-catalyzed esterification and transesterification reaction. Biotechnology and Bioengineering 78(4). PubMed

Budde H. and Flohé L. (2002) Enzymes of the Thiol-dependent hydroperoxide metabolism in pathogens as potential drug targets. In: Thiol metabolism and redox regulation of cellular functions. Edited by Alfonso Pompella, Gábor Bánhegyi, Maria Wellman-Rousseau, IOS Press, Ohmaha NATO Science Series, 347

Flohé L., Budde H., Bruns K., Castro H., Clos J., Hofmann B., Kansal-Kalavar S., Krumme D., Menge U., Plank-Schumacher K., Sztajer H., Wissing J., Wylegalla C. and Hecht H.-J. (2002) Tryparedoxin peroxidase of Leishmania donovani: Molecular cloning, heterologous expression, specificity and catalytic mechanism. Arch Biochem Biophys 397(2) 324-335. PubMed

Hofmann B., Budde H., Bruns K., Guerrero S., Kalisz H., Menge U., Montemartini M., Nogoceke E., Steinert P., Wissing J., Flohé L. and Hecht H.-J. (2001) Structures of Tryparedoxins Revealing Interaction with trypanothione Biol Chem 382 459-471. PubMed