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Adrian Streit

Position: Project Leader
Unit: Streit Sommer
Phone: +49 7071 601 403
Picture of Streit, Adrian



1985 - 1990 Biology studies with main topic Zoology at the University of Berne, Switzerland.

1989 - 1990 Diploma (Masters) student with Prof. Dr. Daniel Schümperli, Institute of Zoology, University of Berne, Switzerland.

1990 - 1994 PhD student with Prof. Dr. Daniel Schümperli, Institute of Zoology, University of Berne, Switzerland.

1994 - 1997 Postdoctoral fellow with Prof. Dr. William B. Wood, Department of MDC Biology, University of Colorado at Boulder, U.S.A.

1997 - 1999 Postdoctoral fellow with Prof. Dr. Monica Steinmann-Zwicky, Institute of Zoology, University of Zürich, Switzerland.

1999 - 2003 Assistant (research and teaching) with Prof. Dr. Fritz Müller, Department of Biology, University of Fribourg, Switzerland.

2003 - 2008 Non-permanent project group leader, MPI for Developmental Biology, Department of Evolutionary Biology, Tübingen, Germany.

Since 2005

Teaching assignment at the University of Tübingen.

 

Since 2008

Tenured project group leader, MPI for Developmental Biology, Department of Evolutionary Biology, Tübingen, Germany.

 

Since 2012 Privatdozent at the University of Tübingen.


Jaleta, T. G., Zhou. S., Bemm, F., Khieu, V., Sinuon, M., Schär, F., Odermatt, P. and Streit, A. (2017). Different but overlapping populations of Strongyloides stercoralis in dogs and humans - dogs as a possible source for zoonotic strongyloidiasis. PLOS Neglected Tropical Diseases, in press.

 

Jaleta, T., G., Roedelsperger, C. and Streit, A. (2017). Parasitological and transcriptomic comparison of Strongyloides ratti infections in natural and in suboptimal permissive hosts. Experimental Parasitology, 180, 112-118 (special issue "Proceedings of the 27th Meeting of the German Society for Parasitology 2016"). DOI:10.1016/j.exppara.2016.12.003

 

Streit, A. (2017). Genetics: Modes of Reproduction and Genetic Analysis. Parasitology, 144, 316-326 (Review, special issue on Strongyloides spp.).

 

Baskaran, P., Jaleta, T. G., Streit, A. and Rödelsperger, C. (2017). Duplications and positive selection drive the evolution of parasitism-associated gene families in the nematode Strongyloides papillosus. Genome Biology and Evolution, 9, 790-801.

 

Streit, A. and Davis, R. E. (2016). Chromatin diminution version 2. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net/, DOI: 10.1002/9780470015902.a0001181.pub2 (Review).

 

Kulkarni, A., Lightfoot, J. W. and Streit, A. (2016). Germline organization in Strongyloides nematodes reveals alternative differentiation and regulation mechanisms. Chromosoma, 125, 725-745.

 

Dulovic, A., Puller, V. and Streit, A. (2016) Optimizing culture conditions for free-living stages of the nematode parasite Strongyloides ratti.Experimental Parasitology, 168, 25-30. 10.1016/j.exppara.2016.06.005.


Streit, A., Wang, J., Kang, Y. and Davis, R. E. (2016). Gene Silencing and Sex Determination by Programmed DNA Elimination in Parasitic Nematodes. Current opinion in Microbiology 32, 120-127 (Review).

 

Hunt, V. L., Tsai, I. J., Coghlan, A., Reid, A. J., Holroyd, N., Foth, B. J., Tracey, A., Cotton, J. A., Stanley, E. J., Beasley, H., Bennett, H., Brooks, K., Harsha, B., Kajitani, R., Kulkarni, A., Harbecke, D., Nagayasu, E., Nichol, S., Ogura, Y., Quail, M., Randle, N., Ribeiro, D., Sanchez-Flores, A., Hayashi, T., Itoh, T., Denver, D. R., Grant, W., Stoltzfus, J. D., Lok, J. B., Murayama, H., Wastling, J., Streit, A., Kikuchi, T., Viney, M. E., Matthew Berriman, M. (2016). The Genomic Basis of Parasitism in the Strongyloides Clade of Nematodes. Nature Genetics, 48, 299-307.

 

Kulkarni, A., Holz, A., Rödelsperger, C., Harbecke, D. and Streit, A. (2016). Differential chromatin amplification and chromosome complements in the germline of Strongyloididae (Nematoda). Chromosoma, 125, 125-136.

 

Guo, L., Chang, Z., Dieterich, C. and Streit, A. (2015). A protocol for chemical mutagenesis in Strongyloides ratti. Experimental Parasitology,158, 2-7 (special issue).

 

Witte, H., Moreno, E., Rödelsperger, C., Kim, J. S., Kim, J. S., Streit, A. and Sommer, R. J. (2015). Gene inactivation using the CRISPR/Cas9 system in the nematode Pristionchus pacificus. Development Genes and Evolution, 225, 55-62.


Hildebrandt, J. C., Eisenbarth, A., Renz, A. and Streit, A. (2014). Reproductive biology of Onchocerca ochengi, a nodule forming filarial nematode in zebu cattle. Veterinary Parasitology 205, 318-329.

 

Streit, A. (2014). How to become a parasite without sex chromosomes: a hypothesis for the evolution of Strogyloides sp. and related nematodes. Parasitology 141, 1244-1254 (Review).


Schär, F., Guo. L., Streit, A., Khieu, V., Sinuon, M., Marti, H. and Odermatt, P. (2014). Strongyloides stercoralis genotypes in humans in Cambodia. Parasitology Inernational 63, 533-536.


Kulkarni, A., Dyka, A., Nemetschke, L., Grant, W. N. and Streit, A. (2013). Parastrongyloides trichosuri suggests that XX/XO sex determination is ancestral in Strongyloididae (Nematode). Parasitology 140, 1822-1830.

 

Rödelsperger, C. and Streit, A. (2013). Komplexität im Kleinen - Nematoden-Genome im Vergleich. BioSpektrum, 06.13, 606-610 (in German).

 

Eisenbarth, A., Ekale, D., Hildebrandt, J. C., Achukwi, M. D, Streit, A. and Renz, A. (2013). Molecular evidence of ‘Siisa form’, a new genotype related to Onchocerca ochengi in cattle from North Cameroon. Acta Tropica 127, 261-265.

 

Rödelsperger, C., Streit, A. and Sommer, R. J. (2012). Structure, function and evolution of the nematode genome. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net/ DOI: 10.1002/9780470015902.a0024603 (Review).


Streit, A. (2012). Silencing by throwing away: a role for chromatin diminution. Developmental Cell, 23, 918-919 (Preview).

 

Hildebrandt, J. C., Eisenbarth, A., Renz, A. and Streit, A. (2012). Single worm genotyping demonstrates that Onchocerca ochengi females simultaneously produce progeny sired by different males. Parasitology Research 111, 2217-2221.

 

Sommer, R. J. and Streit, A. (2011). Comparative Genetics and Genomics of Nematodes: Genome Structure, Development and Lifestyle. Annual Review of Genetics 45, 1-20 (Review).

 

Nemetschke, L., Eberhardt, A. G., Hertzberg, H. and Streit, A. (2010). Genetics, chromatin diminution and sex chromosome evolution in the parasitic nematode genus Strongyloides. Current Biology 20, 1687-1696.

 

Streit, A. and Sommer, R. J. (2010). Genetics: Random expression goes binary Nature, 463, 891-892 (News and Views).


Nemetschke, L., Eberhardt, A. G., Viney, M. E. and Streit, A. (2010). A genetic map of the animal-parasitic nematode Strongyloides ratti. Molecular and Biochemical Parasitiology 169, 124-127.

 

Wegewitz, V., Schulenburg, H. and Streit, A. (2009). Do males facilitate the spread of novel phenotypes within populations of the androdioecious nematode Caenorhabditis elegans? Journal of Nematology, 41, 247-254.

 

Minasaki, R., Puoti, A. and Streit, A. (2009). The DEAD-box protein MEL-46 is required in the germ line of the nematode Caenorhabditis elegans. BMC Developmental Biology 9, 35

 

Ogawa, A., Streit, A., Antebi, A. and Sommer, R. J. (2009). A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes. Current Biology 19, 67-71.

 

Eberhardt, A. G., Mayer, W. E., Bonfoh, B. and Streit, A. (2008). The Strongyloides (Nematoda) of sheep and the predominant Strongyloides of cattle form at least two different, genetically isolated populations. Veterinary Parasitology 157, 89-99.

 

Wegewitz, V., Schulenburg, H. and Streit, A. (2008). Experimental insight into the proximate causes of male persistence variation among two strains of the androdioecious Caenorhabditis elegans (Nematoda). BMC Ecology 8, 12.

 

Streit, A. (2008). Reproduction in Strongyloides (Nematoda): a life between sex and parthenogenesis. Parasitology 135, 285-294 (Review).

 

Eberhardt, A. G., Mayer, W. E. and Streit, A. (2007). The free-living generation of the nematode Strongyloides papillosus undergoes sexual reproduction. International Journal for Parasitology 37, 989-1000.

 

Minasaki, R. and Streit, A. (2007). mel-47, a novel protein required for early cell divisions in the nematode Caenorhabditis elegans. Molecular Genetics and Genomics 277, 315-328.

 

Takacs-Vellai, K., Vellai, T., Puoti, A., Passannante, M., Wicky, C., Streit, A., Kovacs, A. L. and Müller, F. (2005). Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Current Biology 15, 1513-1517.

 

Stoyanov, C. N., Fleischmann, M., Suzuki, Y., Tapparel, N., Gautron, F., Streit, A., Wood, W. B. and Müller, F. (2003). Expression of the C. elegans labial Orthologue ceh-13 during Male Tail Morphogenesis. Developmental Biology 259, 137-149.

 

Streit, A., Kohler, R., Marty, T., Belfiore, M., Takacs-Vellai, K., Maria-Alessandra Vigano, M. A., Schnabel, R., Affolter, M. and Müller, F. (2002). Conserved regulation of the C. elegans labial/ Hox1 gene ceh-13. Developmental Biology 242, 96-108.

 

Streit, A., Bernasconi, L., Sergeev, P. and Steinmann-Zwicky, M. (2002). mgm1, the earliest sex-specific germline marker in Drosophila reflects the expression of the gene esg in male stem cells. International Journal of Developmental Biology 46, 159-166.

 

Sergeev, P., Streit, A., Heller, A. and Steinmann-Zwicky, M. (2001). The Drosophila dorsoventral determinant pipe contains ten copies of a variable exon homologous to mamalian heparan sulfate 2-sulfotransferase. Developmental Dynamics 220, 122-132.

 

Streit, A., Li, W., Robertson, B., Schein, J., Kamal, I. H., Marra, M. and Wood, W. B. (1999). Homologs of the Caenorhabditis elegans masculinizing gene her-1 in Caenorhabditis briggsae and the filarial parasite Brugia malayi. Genetics 152, 1573-1584.

 

Li, W., Streit, A., Robertson, B. and Wood, W. B. (1999). Evidence for multiple promoter elements orchestrating male-specific regulation of the her-1 gene in C. elegans. Genetics 152, 237-248.

 

Wood, W. B., Streit, A. and Li, W. (1997). Dosage compensation: X-repress yourself. Current Biology 7, R227-R230 (Dispatch).

 

Spycher, C., Streit, A., Stefanovic, B., Albrecht, D., Wittop Koning, T. H. and Schümperli, D. (1994). 3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA. Nucleic Acids Research 22, 4023-4030.

 

Streit, A., Wittop Koning, T., Soldati, D., Melin, L. and Schümperli, D. (1993). Variable effects of the conserved RNA hairpin element upon 3' end processing of histone pre-mRNA in vitro. Nucleic Acids Research 21, 1569-1575.

 

Melin, L., Soldati, D., Mital, R., Streit, A. and Schümperli, D. (1992). Biochemical demonstration of complex formation of histone pre-mRNA with U7 small nuclear ribonucleoprotein and hairpin binding factors. EMBO Journal 11, 691-697.

 

Gruber, A., Streit, A., Reist, M., Benninger, P., Böhni, R. and Schümperli, D. (1990). Structure of a mouse histone-encoding gene cluster. Gene 95, 303-304.