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Publications (Kopie 1)

Publications

since the foundation of Department 2 Biochemistry in July 2006

  1. Huntzinger E, Braun JE, Heimstadt S, Zekri L & Izaurralde E (2010) Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J 29, 4146-60. PubMed
  2. Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN & Izaurralde E (2010) SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes Dev 24, 2440-50. PubMed
  3. Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O & Izaurralde E (2010) The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J 29, 2368-80. PubMed
  4. Boland A, Tritschler F, Heimstädt S, Izaurralde E & Weichenrieder O (2010) Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 11, 522-7. PubMed
  5. Haas G, Braun JE, Igreja C, Tritschler F, Nishihara T & Izaurralde E (2010) HPat provides a link between deadenylation and decapping in metazoa. J Cell Biol 189, 289-302. PubMed
  6. Tritschler F, Huntzinger E & Izaurralde E (2010) Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of deja vu. Nat Rev Mol Cell Biol 11, 379-84. PubMed
  7. Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E & Weichenrieder O (2009) DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A 106, 21591-6. PubMed
  8. Zekri L, Huntzinger E, Heimstadt S & Izaurralde E (2009) The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Mol Cell Biol 29, 6220-31. PubMed
  9. Izaurralde E (2009) Freedom versus constraint in protein function. Nat Rev Mol Cell Biol 10, 372. PubMed
  10. Hansen KD, Lareau LF, Blanchette M, Green RE, Meng Q, Rehwinkel J, Gallusser FL, Izaurralde E, Rio DC, Dudoit S, et al. (2009) Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. PLoS Genet 5, e1000525. PubMed
  11. Eulalio A, Tritschler F & Izaurralde E (2009) The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. RNA 15, 1433-42. PubMed
  12. Izaurralde E & Zamore PD (2009) Nucleus and gene expression. Curr Opin Cell Biol 21, 331-4. PubMed
  13. Wittkopp N, Huntzinger E, Weiler C, Saulière J, Schmidt S, Sonawane M & Izaurralde E (2009) Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol 29, 3517-28. PubMed
  14. Lazzaretti D, Tournier I & Izaurralde E (2009) The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. RNA 15, 1059-66. PubMed
  15. Eulalio A, Helms S, Fritzsch C, Fauser M & Izaurralde E (2009) A C-terminal silencing domain in GW182 is essential for miRNA function. RNA 15, 1067-77. PubMed
  16. Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E & Truffault V (2009) The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res 37, 2974-83. PubMed
  17. Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E & Weichenrieder O (2009) Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell 33, 661-8. PubMed
  18. Khazina E & Weichenrieder O (2009) Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame. Proc Natl Acad Sci U S A 106, 731-6. PubMed
  19. Eulalio A, Huntzinger E, Nishihara T, Rehwinkel J, Fauser M & Izaurralde E (2009) Deadenylation is a widespread effect of miRNA regulation. RNA 15, 21-32. PubMed
  20. Huntzinger E, Kashima I, Fauser M, Saulière J & Izaurralde E (2008) SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14, 2609-17. PubMed
  21. Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E & Truffault V (2008) Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol 28, 6695-708. PubMed
  22. Eulalio A, Huntzinger E & Izaurralde E (2008) Getting to the root of miRNA-mediated gene silencing. Cell 132, 9-14. PubMed
  23. Jinek M, Eulalio A, Lingel A, Helms S, Conti E & Izaurralde E (2008) The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. RNA 14, 1991-8. PubMed
  24. Eulalio A, Huntzinger E & Izaurralde E (2008) GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol 15, 346-53. PubMed
  25. Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E & Weichenrieder O (2007) A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol 27, 8600-11. PubMed
  26. Eulalio A, Rehwinkel J, Stricker M, Huntzinger E, Yang SF, Doerks T, Dorner S, Bork P, Boutros M & Izaurralde E (2007) Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev 21, 2558-70. PubMed
  27. Dorner S, Eulalio A, Huntzinger E & Izaurralde E (2007) Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms. EMBO Rep 8, 723-9. PubMed
  28. Behm-Ansmant I, Kashima I, Rehwinkel J, Saulière J, Wittkopp N & Izaurralde E (2007) mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. FEBS Lett 581, 2845-53. PubMed
  29. Eulalio A, Behm-Ansmant I, Schweizer D & Izaurralde E (2007) P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol 27, 3970-81. PubMed
  30. Behm-Ansmant I, Gatfield D, Rehwinkel J, Hilgers V & Izaurralde E (2007) A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J 26, 1591-601. PubMed
  31. Eulalio A, Behm-Ansmant I & Izaurralde E (2007) P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 8, 9-22. PubMed
  32. Jacobson A & Izaurralde E (2007) Nonsense-mediated mRNA decay: from yeast to metazoan. In Book Nonsense-mediated mRNA decay: from yeast to metazoan 3 edit. (Matthews M, Sonenberg N & Hershey JWB, eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
  33. Behm-Ansmant I & Izaurralde E (2007) NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway. In Book NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway (Maquat LE, ed.), pp. 151-163. Landes Bioscience, Georgetown, Texas, USA.
  34. Glavan F, Behm-Ansmant I, Izaurralde E & Conti E (2006) Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. EMBO J 25, 5117-25. PubMed
  35. Rehwinkel J, Raes J & Izaurralde E (2006) Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends Biochem Sci 31, 639-46. PubMed
  36. Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P & Izaurralde E (2006) mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 20, 1885-98. PubMed
  37. Rehwinkel J, Natalin P, Stark A, Brennecke J, Cohen SM & Izaurralde E (2006) Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Mol Cell Biol 26, 2965-75. PubMed
  38. Weigel D & Izaurralde E (2006) A tiny helper lightens the maternal load. Cell 124, 1117-8. PubMed
  39. Behm-Ansmant I & Izaurralde E (2006) Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes Dev 20, 391-8. PubMed