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Vincent Truffault

Position: Projektleiter
Abteilung: Truffault
Tel.: 07071 601 1359
Bild von Truffault, Vincent



  • PhD 2002 Technical University of Munich, Germany
  • 2002-2004 Postdoctoral fellow at the University of Utrecht, The Netherlands
  • 2004-2007 Postdoctoral fellow at MPI for Developmental Biology, Dept of Protein Evolution, Germany
  • since 2007 Project leader at the MPI for Developmental Biology, Dept of Biochemistry, Tübingen, Germany

Peter D, Weber R, Kone C, Chung MY, Ebertsch L, Truffault V, Weichenrieder O, Igreja C & Izaurralde E (2015) Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Genes Dev 29, 1835-49. PubMed


Kadjane P, Platas-Iglesias C, Boehm-Sturm P, Truffault V, Hagberg GE, Hoehn M, Logothetis NK & Angelovski G (2014) Dual-frequency calcium-responsive MRI agents. Chemistry 20, 7351-62. PubMed


Eisenbeis S, Proffitt W, Coles M, Truffault V, Shanmugaratnam S, Meiler J & Hocker B (2012) Potential of fragment recombination for rational design of proteins. J Am Chem Soc 134, 4019-22. PubMed


Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M & Izaurralde E (2012) A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nat Struct Mol Biol 19, 1324-31. PubMed


Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E & Sprangers R (2011) The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J 31, 279-90. PubMed


Khazina E, Truffault V, Buttner R, Schmidt S, Coles M & Weichenrieder O (2011) Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition. Nat Struct Mol Biol 18, 1006-14. PubMed


Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O & Izaurralde E (2010) The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J 29, 2368-80. PubMed


Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E & Weichenrieder O (2009) DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A 106, 21591-96. PubMed


Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E, & Truffault V. (2009) The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res37, 2974–2983. PubMed


Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E & Weichenrieder O. (2009). Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell. 33, 661–668. PubMed


Feige MJ, Groscurth S, Marcinowski M, Yew ZT, Truffault V, Paci E, Kessler H, & Buchner J (2008) The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity. Proc Natl Acad Sci U S A. 105, 13373-8. PubMed


Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E, & Truffault V (2008) Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol. 28, 6695-708.PubMed


de Jong RN, Truffault V, Diercks T, Ab E, Daniels MA, Kaptein R, & Folkers GE (2008) Structure and DNA binding of the human Rtf1 Plus3 domain. Structure16, 149-59. PubMed


Ammelburg M, Hartmann MD, Djuranovic S, Alva V, Koretke KK, Martin J, Sauer G, Truffault V, Zeth K, Lupas AN, & Coles M (2007) A CTP-dependent archaea riboflavin kinase forms a bridge in the evolution of cradle-loop barrels. Structure15, 1577-90. PubMed


Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E & Weichenrieder O (2007) A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol. 27, 8600-11. PubMed


Coles M, Hulko M, Djuranovic S, Truffault V, Koretke K, Martin J, & Lupas AN (2006) Common evolutionary origin of swapped-hairpin and double-psi beta barrels. Structure14, 1489-98. PubMed


Grenha R, Rzechorzek NJ, Brannigan JA, de Jong RN, AB E, Diercks T, Truffault V, Ladds JC, Fogg MJ, Bongiorni C, Perego M, Kaptein R, Wilson KS, Folkers GE, & Wilkinson AJ (2006) Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli. J Biol Chem281, 37993-8003. PubMed


Hulko M, Berndt F, Gruber M, Linder JU, Truffault V, Schultz A, Martin J, Schultz JE, Lupas AN, & Coles M (2006) The HAMP domain structure implies helix rotation in transmembrane signaling. Cell126, 929-40. PubMed


de Jong RN, Ab E, Diercks T, Truffault V, Daniels M, Kaptein R, & Folkers GE (2006) Solution structure of the human ubiquitin-specific protease 15 DUSP domain. J Biol Chem281, 5026-31. PubMed


Patterson HM, Brannigan JA, Cutting SM, Wilson KS, Wilkinson AJ, AB E, Diercks T, de Jong RN, Truffault V, Folkers GE, & Kaptein R (2005) The structure of bypass of forespore C, an intercompartmental signaling factor during sporulation in Bacillus. J Biol Chem280, 36214-20. PubMed


Coles M, Duranovic S, Söding J, Frickey T, Koretke K, Truffault V, Martin J, & Lupas AN (2005) AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels. Structure13, 919-28. PubMed


Haupt M, Coles M, Truffault V, Bramkamp M, Altendorf K, & Kessler H (2004) 1H, 13C and 15N resonance assignment of the nucleotide binding domain of KdpB from Escherichia coli. J Biomol NMR29, 437-8. PubMed


Schmiedeberg N, Schmitt M, Rölz C, Truffault V, Sukopp M, Bürgle M, Wilhelm OG, Schmalix W, Magdolen V, & Kessler H (2002) Synthesis, solution structure, and biological evaluation of urokinase type plasminogen activator (uPA)-derived receptor binding domain mimetics. J Med Chem45, 4984-94. PubMed


Gruner SA, Truffault V, Voll G, Locardi E, Söckle M, & Kessler H (2002) Design, synthesis, and NMR structure of linear and cyclic oligomers containing novel furanoid sugar amino acids. Chemistry8, 4365-76. PubMed


Truffault V, Coles M, Diercks T, Abelmann K, Eberhardt S, Lüttgen H, Bacher A, & Kessler H (2001) The solution structure of the N-terminal domain of riboflavin synthase. J Mol Biol309, 949-60. PubMed