Molecular Biology

Adaption to Changes

Director: Detlef Weigel
Assistant: Hülya Wicher
Phone: +49 7071 601-1411
Fax: +49 7071 601-1412


Staff: Alphabetical List
References: Publication List


For more information, please visit our Department Website

Introduction

The long-term goal of our research is to understand both the molecular mechanisms and the evolution of adaptive traits. To this end, we are using both phenotype-first and genotype-first approaches to identify genetic variants with a potential role in local, regional or global adaptation. Such studies benefit tremendously from knowledge about the genomes of other species, as well from a historical perspective that exploits ancient DNA methods to unlock the knowledge stored in herbaria. One of our lines of research, on fitness tradeoffs, is now being supported through a grant from the ERC. You can read the application here.


Apart from scientific discoveries, training the next generation of leaders in the field is very important to us. Many former members have established successful careers, and several have won major scientific prizes and awards. There is a range of exciting opportunities to perform cutting-edge work in the department, and we are always interested in hearing from undergraduates, PhD students and postdocs who want to be part of our team.

Research Topics

1135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana
1001 Genomes Consortium Cell (2016), 166(2) 481-91.

Century-scale methylome stability in a recently diverged Arabidopsis thaliana lineage
Hagmann J., Becker C., Muller J., Stegle O., Meyer R. C., Wang G., Schneeberger K., Fitz J., Altmann T., Bergelson J., Borgwardt K. and Weigel D.
PLoS Genet (2015), 11(1) e1004920.

Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles
Todesco M., Kim S. T., Chae E., Bomblies K., Zaidem M., Smith L. M., Weigel D. and Laitinen R. A.
PLoS Genet (2014), 10(7) e1004459.

Evolution of DNA methylation patterns in the Brassicaceae is driven by differences in genome organization
Seymour D. K., Koenig D., Hagmann J., Becker C. and Weigel D.
PLoS Genet (2014), 10(11) e1004785.

Species-wide Genetic Incompatibility Analysis Identifies Immune Genes as Hot Spots of Deleterious Epistasis
Chae E., Bomblies K., Kim S. T., Karelina D., Zaidem M., Ossowski S., Martin-Pizarro C., Laitinen R. A., Rowan B. A., Tenenboim H., Lechner S., Demar M., Habring-Muller A., Lanz C., Ratsch G. and Weigel D.
Cell (2014), 159(6) 1341-