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Dr. Oliver Weichenrieder

Project Leader, Retrotransposition and Regulatory RNAs

Oliver WeichenriederDepartment 2 (Biochemistry)

Retrotransposition and Regulatory RNAs


MPI for Developmental Biology, Spemannstr. 35 / II, 72076 Tübingen, Germany

Tel: +49 7071 601 1358
Fax: +49 7071 601 1353
E-Mail: oliver.weichenrieder [AT] tuebingen [DOT] mpg [DOT] de


Biography


  • PhD 1999    EMBL Grenoble, France / University of Heidelberg, Germany
  • 1999-2000    Postdoctoral fellow, EMBL Grenoble, France
  • 2000-2006    Postdoctoral fellow and Research Associate, The Netherlands Cancer Institute, Amsterdam, The Netherlands
  • since 2006    Project Leader at the MPI for Developmental Biology, Dept of Biochemistry, Tübingen, Germany

Publications


  1. Sauer E & Weichenrieder O (2011) Structural basis for RNA 3'-end recognition by Hfq. Proc Natl Acad Sci U S A 108, 13065-70. PubMed
  2. Khazina E, Truffault V, Buttner R, Schmidt S, Coles M & Weichenrieder O (2011) Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition. Nat Struct Mol Biol 18, 1006-14. PubMed
  3. Boland A, Huntzinger E, Schmidt S, Izaurralde E & Weichenrieder O (2011) Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci U S A 108, 10466-71. PubMed
  4. Boland A, Tritschler F, Heimstadt S, Izaurralde E & Weichenrieder O (2010) Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 11, 522-7. PubMed
  5. Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O & Izaurralde E (2010) The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. EMBO J 29, 2368-80. PubMed
  6. Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E & Weichenrieder O (2009) DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A 106, 21591-96. PubMed
  7. Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E & Truffault V (2009) The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res 37, 2974-83. PubMed
  8. Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E & Weichenrieder O (2009) Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell 33, 661-8. PubMed
  9. Khazina E & Weichenrieder O (2009) Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame. Proc Natl Acad Sci U S A 106, 731-6. PubMed
  10. Fernandez-Santiago R, Hoenig S, Lichtner P, Sperfeld AD, Sharma M, Berg D, Weichenrieder O, Illig T, Eger K, Meyer T, et al. (2009) Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. J Neurol 256, 1337-1342. PubMed
  11. Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E & Truffault V (2008) Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Mol Cell Biol 28, 6695-708. PubMed
  12. Bennett EA, Keller H, Mills RE, Schmidt S, Moran JV, Weichenrieder O & Devine SE (2008) Active Alu retrotransposons in the human genome. Genome Res 18, 1875-83. PubMed
  13. Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E & Weichenrieder O (2007) A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Mol Cell Biol 27, 8600-11. PubMed
  14. Repanas K, Zingler N, Layer LE, Schumann GG, Perrakis A & Weichenrieder O (2007) Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease. Nucleic Acids Res 35, 4914-26. PubMed
  15. Buchwald G, van der Stoop P, Weichenrieder O, Perrakis A, van Lohuizen M & Sixma TK (2006) Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J 25, 2465-74. PubMed
  16. Müller M, Weigand JE, Weichenrieder O & Suess B (2006) Thermodynamic characterization of an engineered tetracycline-binding riboswitch. Nucleic Acids Res 34, 2607-17. PubMed
  17. Zingler N, Weichenrieder O & Schumann GG (2005) APE-type non-LTR retrotransposons: determinants involved in target site recognition. Cytogenet Genome Res 110, 250-68. PubMed
  18. Weichenrieder O, Repanas K & Perrakis A (2004) Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon. Structure 12, 975-86. PubMed
  19. Huck L, Scherrer A, Terzi L, Johnson AE, Bernstein HD, Cusack S, Weichenrieder O & Strub K (2004) Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain. Nucleic Acids Res 32, 4915-24. PubMed
  20. Wild K, Weichenrieder O, Strub K, Sinning I & Cusack S (2002) Towards the structure of the mammalian signal recognition particle. Curr Opin Struct Biol 12, 72-81. PubMed
  21. Weichenrieder O, Stehlin C, Kapp U, Birse DE, Timmins PA, Strub K & Cusack S (2001) Hierarchical assembly of the Alu domain of the mammalian signal recognition particle. RNA 7, 731-40. PubMed
  22. Weichenrieder O, Wild K, Strub K & Cusack S (2000) Structure and assembly of the Alu domain of the mammalian signal recognition particle. Nature 408, 167-73. PubMed
  23. Wild K, Weichenrieder O, Leonard GA & Cusack S (1999) The 2 A structure of helix 6 of the human signal recognition particle RNA. Structure 7, 1345-52. PubMed
  24. Weichenrieder O, Kapp U, Cusack S & Strub K (1997) Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14. RNA 3, 1262-74. PubMed
  25. Jones JT, Barnes CL, Lietzke SE, Weichenrieder O, Doudna JA & Kundrot CE (1996) Preliminary X-ray diffraction studies of an RNA pseudoknot that inhibits HIV-1 reverse transcriptase. Acta Crystallogr D Biol Crystallogr 52, 1018-20. PubMed

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last modified 2011-10-31