Welcome to the Ley Lab Home Page. We are now the Department of Microbiome Science, Max Planck Institute for Developmental Biology, Tübingen, Germany. For opportunities to join the lab, please visit the Join Us page. Research Focus: We are interested in the co-evolution of humans with their microbiomes.
The microbiome is environmentally acquired when people are born and rapidly builds up on the body's surfaces to constitute a critically important layer of cells. The majority of microbial cells inhabit the gastrointestinal tract, where they provide fundamental services to the host, from digestion of dietary fiber to pathogen exclusion. The composition of microbiomes varies between individuals in composition and function. Functional differences can in turn impact health. The microbiome is increasingly viewed as a target for therapeutic interventions for diseases ranging from malnutrition to chronic inflammation.
Goodrich, J. K. , E. R. Davenport, M. A. Jackson, M. Beaumont, R. Knight, T. D. Spector, J. T. Bell, A. G. Clark, R. E. Ley. Genetic determinants of the gut microbiome assessed in UK Twins. Cell Host & Microbe 19:731-43. (2016)
Goodrich*, J. K., E. R. Davenport*, J. L. Waters*, A. G. Clark and R. E. Ley. Cross-species comparisons of host genetic associations with the microbiome. Science 352: 532-535. (2016)
Goodrich, J. K., J. L. Waters, A. C. Poole, J. L. Sutter, O. Koren, R. Blekhman, M. Beaumont, W. Van Treuren, R. Knight, J. T. Bell, T. D. Spector, A. G. Clark and R. E. Ley. Human genetics shape the gut microbiome. Cell 159: 789-799. (2014)
Cullender, T. C., B. Chassaing, A. Janzon, K. Kumar, C. Muller, J. J. Werner, L. T. Angenent, M. E. Bell, A. G. Hay, D. A. Peterson, J. Walter, M. Vijay-Kumar, A. T. Gewirtz and R. E. Ley. Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe 14: 571-581. (2013)
DiRienzi*, S. C., I. Sharon*, K. C. Wrighton, O. Koren, L. A. Hug, B. C. Thomas, J. K. Goodrich, J. T. Bell, T. D. Spector, J. F. Banfielda and R. E. Ley. The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria. eLife 2:e01102 (2013)
Koren, O., J. K. Goodrich, T. C. Cullender, A. Spor, K. Laitinen, H. Backhed, A. Gonzalez, J. J. Werner, L. T. Angenent, R. Knight, F. Backhed, E. Isolauri, S. Salminen and R. E. Ley. Remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150: 1-11 (2012).