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Publications

2014
Stiel, A., Feldmeier, K. & Höcker, B. (2014) Identification of protein scaffolds for enzyme design using ScaffoldSelection. Methods Mol Biol 1216:183-96. [PubMed]
 
Farias-Rico, J.A., Schmidt, S. & Höcker, B. (2014) Evolutionary relationship of two ancient protein superfolds. Nature Chem Biol 10:710-5. [PubMed]
 
Höcker, B. (2014) Design of proteins from smaller fragments - learning from evolution. Curr Opin Struc Biol 27:56-62. [PubMed][fulltext]
 
Höcker, B. & Midelfort, K. (2014) Editorial: Designing protein function - Macromolecular design. J Struc Biol 185:135. [PubMed] - Editorial to the special issue on "Macromolecular Design" edited by Katarina & myself
 
Scheib, U., Shanmugaratnam, S., Farias-Rico, J.A. & Höcker, B. (2014) Change in protein-ligand specificity through binding pocket grafting. J Struc Biol 185:186-92. doi: 10.1016/j.jsb.2013.06.002. Epub 2013 Jun17. [PubMed]
 
2013
Feldmeier, K. & Höcker, B. (2013) Computational protein design of ligand binding and catalysis. Curr Opin Chem Biol 17:929–933.[PubMed]http://elsarticle.com/1ejkdZv
 
Höcker, B. (2013) Engineering chimaeric proteins from fold fragments: 'hopeful monsters' in protein design. Biochem Soc Trans 41:1137-40. [PubMed]
 
Meier, M.M.,Rajendran, C., Malisi, C., Fox, N.G., Xu, C., Schlee, S., Barondeau, D.P., Höcker, B., Sterner, R. & Raushel, F.M. (2013) Molecular Engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template. J Am Chem Soc 135, 11670-7. [PubMed]
 
Farias-Rico, J.A. & Höcker, B. (2013) Design of chimeric proteins by combination of subdomain-sized fragments. Methods Enzymol 523, 389-405. [PubMed]
 
 
2012
Malisi, C., Schumann, M., Toussaint, N.C., Kageyama, J., Kohlbacher, O. & Höcker, B. (2012) Binding pocket optimization by computational protein design.                                   
PLoS One 7(12):e52505. [PubMed]
 
Höcker, B. (2012) A toolbox for protein design. Nature 491, 204-5. [PubMed]                                                             
News & Views on Koga et al. (2012): Principles for designing ideal protein structures.
 
Shanmugaratnam, S., Eisenbeis, S. & Höcker, B. (2012) A highly stable protein chimera built from fragments of different folds. Protein Eng Des Sel 25, 699-703. [PubMed]
 
Höcker, B. (2012) A metalloenzyme reloaded. Nature Chem Biol 8, 224-5. [PubMed]                                         
News & Views on Khare et al. (2012): Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
 
Eisenbeis, S., Proffitt, W., Coles, M., Truffault, V., Shanmugaratnam, S., Meiler, J. & Höcker, B. (2012) The potential of fragment recombination for the rational design of proteins. 
J Am Chem Soc 134, 4019-22. [PubMed
 
 
2011
Höcker, B. Einblicke in die Mechanismen der Evolution durch Protein Design. Jahrbuch der Akademie der Wissenschaften zu Göttingen 2011, S. 183-187, De Gruyter.
 
Malisi, C., Stiel, A.C. & Höcker, B. (2011) Enzyme am Reißbrett. BIOspektrum 7, 736-8. [BIOspektrum]
 
 
2010
Höcker, B. (2010) Mechanismen der Evolution als Matrize für Protein Engineering. (Forschungsbericht 2010 - MPI für Entwicklungsbiologie).
 
Schreier, B. & Höcker, B. (2010) Engineering the enolase magnesium II bindding site: implications for its evolution. Biochemistry 49, 7582-9. [PubMed]
 
Eisenbeis, S. & Höcker, B. (2010) Evolutionary mechanism as a template for protein engineering. J Pep Sci 16, 538-44. [PubMed]
 
Höcker, B. (2010) Metals make proteins stick. Chem Biol 17, 103-4. [PubMed]
Preview on Salgado et al. (2010): Metal templated design of protein interfaces.
 
 
2009
Schreier, B., Stumpp, C., Wiesner, S. & Höcker, B. (2009) Computational design of ligand binding is not a solved problem. Proc Natl Acad Sci 106, 18491-6. [PubMed]   
Media coverage in Nature News & in The Scientist  
 
Malisi, C., Kohlbacher, O. & Höcker, B. (2009) Automated scaffold selection for enzyme design. Proteins 77, 74-83. [PubMed]
 
Claren, J., Malisi, C., Höcker, B. & Sterner, R. (2009) Establishing wild-type levels of catalytic activity on natural and artificial (βα)8-barrel protein scaffolds.
Proc Natl Acad Sci 106, 3704-9. [PubMed]  
 
Höcker, B., Lochner, A., Seitz, T., Claren, J. & Sterner, R. (2009) High-resolution crystal structure of an artificial (βα)8-barrel protein designed from identical half-barrels. Biochemistry 48, 1145-1147. [PubMed]
 
 
2008
Höcker, B. Chapter 8: Structural frameworks suitable for engineering. In Protein Engineering Handbook. Eds. S.Lutz & U.T.Bornscheuer. Wiley-VCH 2008.
 
Bharat, T.A.M., Eisenbeis, S., Zeth, K. & Höcker, B. (2008) A βα-barrel built by the combination of fragments from different folds. 
Proc Natl Acad Sci 105, 9942-7. [PubMed]  
 
Höcker, B. (2008). Proteindesign und -engineering. Trendbericht in Biochemie und Molekularbiologie. Nachrichten aus der Chemie 56/3, 298-301. [GDCh]
 
 
For earlier publications see group member pages