Veröffentlichungen

Renschler FA, Bruekner SR, Salomon PL, Mukherjee A, Kullmann L, Schütz-Stoffregen MC, Henzler C, Pawson T, Krahn MP, Wiesner S. Structural basis for the interaction between the cell polarity proteins Par3 and Par6. Sci Signal. 2018 Feb 13;11(517).

Beati H, Peek I, Hordowska P, Honemann-Capito M, Glashauser J, Renschler FA, Kakanj P, Ramrath A, Leptin M, Luschnig S, Wiesner S, Wodarz A. The adherens junction-associated LIM domain protein smallish regulates epithelial morphogenesis. J Cell Biol. 2018 Mar 5;217(3):1079-1095.

Wurm JP, Holdermann I, Overbeck JH, Mayer PHO, Sprangers R. Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6034-6039.

Schütz S, Nöldeke ER, Sprangers R. A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping. Nucleic Acids Res. 2017 Jun 20;45(11):6911-6922.

Cvetkovic MA, Wurm JP, Audin MJ, Schütz S, Sprangers R. The Rrp4-exosome complex recruits and channels substrate RNA by a unique mechanism. Nat Chem Biol. 2017 May;13(5):522-528.

Cakić N, Savić T, Stricker-Shaver J, Truffault V, Platas-Iglesias C, Mirkes C, Pohmann R, Scheffler K, Angelovski G. Paramagnetic lanthanide chelates for multicontrast MRI. Chem Commun (Camb). 2016 Jul 28;52(59):9224-7.

Zhu H, Sepulveda E, Hartmann MD, Kogenaru M, Ursinus A, Sulz E, Albrecht R, Coles M, Martin J, Lupas AN. Origin of folded repeat protein from an intrinsically disordered ancestor. Elife. 2016 Sep 13;5. pii: e16761.

Fuchs AL, Neu A, Sprangers R. A general methods for rapid and cost-efficient large-scale production of 5' capped RNA. RNA. 2016 Sep;22(9):1454-66.

Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y, Hothorn M, Mayer A. Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains. Science. 2016 May 20;352(6288):986-90.

Audin MJ, Wurm JP, Cvetkovic MA, Sprangers R. The oligomeric architecture of the archaeal exosome is important for processive and efficient RNA degradation. Nucleic Acids Res. 2016 Apr 7;44(6):2962-73.

Martinez J, Truffault V, Hothorn M. Structural determinants ofr substrate binding and catalysis in triphosphate tunnel metalloenzymes. J Biol Chem. 2015 Sep 18;290(38):23348-60.

Wiesner S, Sprangers R. Methyl groups as NMR probes for biomolecular interaction. Curr Opin Struct Biol. 2015 Dec;35:60-7.

Neu A, Neu U, Fuchs AL, Schlager B, Sprangers R. An excess of catalytically required motions inhibits the scavenger decapping enzyme. Nat Chem Biol. 2015 Sep;11(9):697-704.

Korycinski M, Albrecht R, Ursinus A, Hartmann MD, Coles M, Martin J, Dunin-Horkawicz S, Lupas AN. STAC—A new domain associated with transmembrane solute transport and two-component signal transduction systems. J Mol Biol. 2015 Oct 9;427(20):3327-3339.

Hartmann MD, Boichenko I, Coles M, Lupas AN, Hernandez Alvarez B. Structural dynamics of the cereblon ligand binding domain. PLoS One. 2015 May 29;10(5):e0128342.

Hartmann MD, Boichenko I, Coles M, Zanini F, Lupas AN, Hernandez Alvarez B. Thalidomide mimics uridine binding to an aromatic cage in cereblon. J Struct Biol. 2014 Dec;188(3):225-32.

Mari S, Ruetalo N, Maspero E, Stoffregen MC, Pasqualato S, Polo S, Wiesner S. Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases. Structure. 2014 Nov 4;22(11):1639-49.

Fromm SA, Kamenz J, Nöldeke ER, Neu A, Zocher G, Sprangers R. In vitro reconstruction of a cellular phase-transition process that involves the mRNA decapping machinery. Angew Chem Int Ed Engl. 2014 Jul 7;53(28):7354-9.

Ferris HU, Coles M, Lupas AN, Hartmann MD. Crystallographic snapshot of the escherichia coli EnvZ histidine kinase in an active conformation. J Struct Biol. 2014 Jun;186(3):376-9.

Mund M, Overbeck JH, Ullmann J, Sprangers R. LEGO-NMR spectroscopy: a method to visualize individual subunits in large heteromeric complexes. Angew Chem Int Ed Engl. 2013 Oct 18;52(43):11401-5.

Audin MJ, Dorn G, Fromm SA, Reiss K, Schütz S, Vorländer MK, Sprangers R. The archaeal exosome: identification and quantification of site-specific motions that correlate with cap and RNA binding. Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8312-6.

Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E. A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleotic degradation. Nat Struct Mol Biol. 2012 Dec;19(12):1324-31.

Stoffregen MC, Schwer MM, Renschler FA, Wiesner S. Methionine scanning as an NMR tool for detecting and analyzing biomolecular interaction surfaces. Structure. 2012 Apr 4;20(4):573-81.

Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E, Sprangers R. The structural basis of Edc3- and Sdc6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J. 2012 Jan 18;31(2):279-90.

Ferris HU, Dunin-Horkawicz S, Hornig N, Hulko M, Martin J, Schultz JE, Zeth K, Lupas AN, Coles M. Mechanism of regulation of receptor histidine kinases. Structure. 2012 Jan 11;20(1):56-66.

Eisenbeis S, Proffitt W, Coles M, Truffault V, Shanmugaratnam S, Meiler J, Höcker B. Potential of fragment recombination for rational design of proteins. J Am Chem Soc. 2012 Mar 7;134(9):4019-22.

Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E, Sprangers R. The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. EMBO J. 2012 Jan 18;31(2):279-90.

Khazina E, Truffault V, Büttner R, Schmidt S, Coles M, Weichenrieder O. Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition. Nat Struct Mol Biol. 2011 Aug 7;18(9):1006-14.

Mund M, Neu A, Ullmann J, Neu U, Sprangers R. Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings. J Mol Biol. 2011 Nov 25;414(2):165-76.

Ferris HU, Dunin-Horkawicz S, Mondéjar LG, Hulko M, Hantke K, Martin J, Schultz JE, Zeth K, Lupas AN, Coles M. The mechanisms of HAMP-mediated signaling in transmembrane receptors. Structure. 2011 Mar 9;19(3):378-85.

Diercks T, Truffault V, Coles M, Millet O. Diagonal-free 3D/4D HN,HN-TROSY-NOESY-TROSY. J Am Chem Soc. 2010 Feb 24;132(7):2138-9.

Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E, Weichenrieder O. DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21591-6.

Alva V, Dunin-Horkawicz S, Habeck M, Coles M, Lupas AN. The GD bo: a widespread noncontiguous supersecondary structural element. Protein Sci. 2009 Sep;18(9):1961-6.

Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E, Truffault V. The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res. 2009 May;37(9):2974-83.