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Tübingen1 Screen: phenotypic groups
Genes identified in the Tübingen1 Screen: phenotypic groups
A-H | I-P | Q-Z
| PHENOTYPIC GROUP | SUBGROUP | Genes * | Genes (N) | Alleles (N) | Alleles/ gene |
Unre- solved (N) |
REFERENCE |
| EARLY | Epiboly | hab, ava, law, weg, (yob) | 4 | 4 | 1.0 | 0 | Kane et al., 1996 |
| Early arrest and necrosis | zom, spb, spr, trl, kap, ban, ogr, plt, niv, ghl, hrp | 11 | 18 | 1.6 | 0 | Kane et al., 1996a | |
| BODY AXES | Dorsalised | swr, snh, pgy, laf, sbn | 5 | 19 | 4.8 | 5 | Mullins et al., 1996 |
| Ventralised | mes, din | 2 | 4 | 2.0 | 0 | Hammerschmidt et al., 1996a | |
| Others | ppt, spt, tri, bib, udu, kgg, sam, sch, ind, mpt | 10 | 17 | 1.7 | 2 | Hammerschmidt et al., 1996 | |
| Prechordal plate, hatching | dns, zja, oep | 4 | 4 | 1.0 | 3 | Hammerschmidt et al., 1996 | |
| MESODERM | Notochord formation | flh, mom, doc, ntl, (din) | 4 | 9 | 2.3 | 0 | Odenthal et al., 1996 |
| Notochord differentiation | hap, sny, dop, sly, gup, bal | 6 | 45 | 7.5 | 0 | Odenthal et al., 1996 | |
| Undulated notochord | qam, ctd, wat, ziz, kik | 5 | 13 | 2.6 | 0 | Odenthal et al., 1996 | |
| Degenerating notochord, late notochord defects | luc, blo, kon, (acc, beo, zim, tnt, sla, roc, baj, que, exp, pun, diw) | 3 | 4 | 1.3 | 18 | Odenthal et al., 1996 | |
| Somite formation | fss, bea, des, aei, (sap, wit) | 4 | 19 | 4.8 | 1 | van Eeden et al.,1996 | |
| Somite patterning | syu, you, yot, ubo, (ntl, mom, flh, doc, con, cho) | 4 | 7 | 1.8 | 0 | van Eeden et al., 1996 | |
| CNS | Forebrain | mbl, kas, slb, (cyc) | 3 | 4 | 1.3 | 1 | Heisenberg et al., 1996 |
| Midbrain-hindbrain | ace, noi | 2 | 7 | 3.5 | 0 | Brand et al., 1996 | |
| Hindbrain, a. o. | snk, pac, nat, wit, atl, ele, ott, ful, bid, vip, win, wis, sbd | 13 | 26 | 2.0 | 0 | Jiang et al., 1996 | |
| Brain degeneration** | (rec, aoi, mur, awa, yug)** (brd, dfd, van, blc, wei, tin, ger, ivy, sll, bch, fla, dns, stu) | 0 | 0 | 0 | 32 | Furutani-Seiki et al., 1996 | |
| Spinal chord, a. o. | con, cyc, sps, bad, dtr, sur, igu, aqb, stb, slt, mol, smh, (yot) | 12 | 21 | 1.8 | 2 | Brand et al., 1996a | |
| Curly tails | spi, wir, cup, tig, lok, cos, sin, sic, vic, pir, hkn sen, snt | 13 | 58 | 4.4 | 31 | Brand et al., 1996a | |
| ORGANS | Blood | mon, frs, weh, cha, ret, yqe, frx, zin, sau, cdy, cia, gre, mot, pnt, tbr | 15 | 30 | 2.0 | 4 | Ransom et al., 1996 |
| Heart morphology | sug, sco, cas, mil, fau, olp, san, loa, (nat) | 8 | 9 | 1.1 | 0 | Chen et al., 1996 | |
| Heart beat | bre, tan, hip, plk, sth, sih, wea, web, tre, leg, quh, pip, str, sli, (hel, vip, hat, slp, jam, sky) | 14 | 18 | 1.3 | 4 | Chen et al., 1996 | |
| Circulation | byp, kus, (syu, you, yot, con) | 2 | 3 | 1.5 | 0 | Chen et al., 1996 | |
| Liver, gut, kidney | flo, gam, tip, lum, trp, stf, (lok, noi) | 6 | 6 | 1.0 | 0 | Chen et al., 1996 | |
| Eye | bum, rne, kor, sri, hez, mic, dre, lep, uki, (cco, blc, pio, blr, fad, mlk, sbl, coo, bch, fla, ivy, van, mir, fdv, dfd, sll, flo, sug, sah, era, ser, bab, fac, dul) | 9 | 12 | 1.3 | 10 | Heisenberg et al., 1996 | |
| Otoliths | eis, kei, mnl, hst, wup, sub, rst, bks, (clx, blc, cls, stw, nob) | 8 | 29 | 3.6 | 7 | Whitfield et al., 1996 | |
| Ear morphology and lateral line organ | bge, hph, lau, lte, dog, eso, vgo, eps, spk, era, bxe, mtc, hps, (ace, cls, puz, sah, box, ful, dak, snk, ott, clx, wei, lep, dre) | 13 | 19 | 1.5 | 4 | Whitfield et al., 1996 | |
| Fins | frf, nag, rfl, pif, fra, fyd, bla, ika, dak, med, krm, tut, sto, (mes, sub, box, lep, dre, fls, ubo, mon) | 13 | 61 | 4.7 | 5 | van Eeden et al., 1996a | |
| Skin | gsp, ddf, pen, bob | 4 | 9 | 2.3 | 1 | van Eeden et al., 1996a | |
| PIGMENT CELLS |
Pigment cell number and pattern | cls, shd, uns, spa, cho, los, snp, pde, slk, (sal, pfe, mom, tig, ful, flh, wit, mes, ubo, mon) | 9 | 32 | 3.6 | 1 | Kelsh et al., 1996 |
| Melanin pigmentation | gol, alb, sdy, mrd, bry, nkl, pew, led | 8 | 25 | 3.1 | 1 | Kelsh et al., 1996 | |
| Melanophore differentiation | tdo, fad, lnd, sln, fdv, dfd, sah, (qam) | 7 | 21 | 3 | 5 | Kelsh et al., 1996 | |
| Melanophore shape | sas, drp, ger, uni, obs, nir, zwa, mac, sum, tin, fam, pet, lak | 13 | 25 | 1.9 | 2 | Kelsh et al., 1996 | |
| Xanthophores | pfe, kef, sal, esr, edi, yob, clx, til, bri, nob, qua, yoc, tof, fet, ric, tar, bst | 17 | 62 | 3.6 | 0 | Odenthal et al., 1996a | |
| Iridophores | lcl, tnd, hei, bed, dim, tod, mat | 7 | 8 | 1.1 | 1 | Kelsh et al., 1996 | |
| Two cell types affected | cco, pio, pep, pup, pol, mlk, coo, ivy, pun, frk, van, mir, blr, cot | 14 | 40 | 2.9 | 10 | Kelsh et al., 1996 | |
| Three cell types affected | wsh, blc, sbl, puz, bch, wei, sll, bli, stw, pch | 10 | 15 | 1.5 | 1 | Kelsh et al., 1996 | |
| JAW AND GILLS | Flatheads, posterior arches | fla, low, ser, bab, fac, dul, gap, (box, puz, pio, mlk, dak, pic, ger, sbl) | 7 | 11 | 1.6 | 32 | Schilling et al., 1996 |
| Hammerheads, ant. arches | hot, ham, hen, get, stu, jef, suc, dol, koi, hoo, pek, she, (sur, ppt, vgo, con, igu, yot, dtr, slb) | 12 | 22 | 1.8 | 22 | Piotrowski et al., 1996 | |
| MOTILITY | Reduced motility, muscle striation | slo, fro, fub, tur, buf, fap, slw, sne, hem, dus, mah, slp, jam, sky, sap, sof, sml, ruz | 18 | 51 | 2.8 | 12 | Granato et al., 1996a |
| Reduced motility, normal striation | sop, nic, red, hat, hel, unp, sho, two, ali, far, mao, ste, cro,sla, slm, (ubo, syu, yot, flh, wis, wir, box, nor, zwa, sum, tdo, clx, luc, kon, sth, cls) | 15 | 25 | 1.7 | 21 | Granato et al., 1996a | |
| Abnormal motility | acc, zim, beo, diw, que, baj, exp, spo, spc, twi, tnt, roc, way, her, (ntl, doc, mom, nev) | 14 | 35 | 2.5 | 17 | Granato et al., 1996a | |
| ADULTS | Body shape | lil, dml, stp, smf, (sps) | 4 | 4 | 1.0 | 0 | Haffter et al., 1996b |
| Pigment pattern | leo, obe, ase, (sal, pfe, spa) | 3 | 8 | 2.7 | 1 | Haffter et al., 1996b | |
| Eyes | (bum, fdv, kor, rne, yob) | 0 | Haffter et al., 1996b | ||||
| Fins | alf, lof, wan, fls, (frf, krm, mes, pif) | 4 | 4 | 1 | 0 | Haffter et al., 1996b | |
| Pigmentation | (alb, bry, bum, drp, gol, mrd, obs, sdy, shd, tar, brs) | 0 | Haffter et al., 1996b | ||||
| RETINO-TECTAL | Pathfinding | ast, bel, blw, uml, (bal, esr,box, yot, con, til, dtr, igu, tof, gup, pic, sly, dak, cyc) | 4 | 7 | 1.8 | 0 | Karlstrom et al., 1996 |
| Mapping | box, nev, pic, blu, mio, don, brd, (dfd, esr, noi, dak, ace, mao, til) | 7 | 23 | 3.3 | 14 | Trowe et al., 1996 | |
| TOTAL | 369 | 892 | 2.4 | 271 |
*Genes in brackets are dealt with predominantly in a paper describing a different class of mutants.
**This class of mutants was not kept systematically (Furutani-Seiki et al., 1996).
From: Haffter, P., Granato, M., Brand, M., Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., van Eeden, F. J. M., Jiang, Y.-J., Heisenberg, C.-P., Kelsh, R. N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C. and Nüsslein-Volhard, C. (1996a). The identification of Genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123, 1-36.
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last modified
2006-08-29