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Tübingen 1 Screen I - P
Genes identified in the Tübingen 1 Screen: I - P
A-H | Q-Z | Phenotypic groups
| iguana igu |
tm79a, ts294e | d1 | embryonic lethal | Tail curled down, floor plate and neurocoel not properly formed. Horizontal myoseptum not formed in posterior somites in the stronger allele tm79a, but present in ts294e . Floor plate clearly visible, but irregular at 36h. Dorsal aorta present (unlike con and yot). In alcian blue stainings, all elements of lower and upper jaw present but sometimes reduced. Strong deletion of mid-ventral brain case. Particularly in embryos with extreme eye fusion, the ethmoid plate is disconnected or absent, and the trabeculae are severely shortened. | Brand et al. 1996a, Karlstrom et al. 1996, Piotrowski et al. 1996 |
| ikarus ika |
tm127c | d3 | adult viable | No or tiny pectoral fins in embryos and adults. No obvious swimming problem, pelvic fins present in homozygous adults. | van Eeden et al. 1996a |
| indigested ind |
ti228e | d5 | adult viable | d5, remnants of the yolk exhibit a dark brown colour. Homozygous adults are viable and fertile. Embryos from homozygous females are normal, except for the appearance of dark globules inside of the chorion, in the periembryonic space. | Hammerschmidt et al. 1996 |
| ivory ivy |
tm271a, tp30 | d4 | embryonic lethal | Pale melanin, especially in melanophores; by d5 most melanophores are small, spot-like and beginning to collect abnormally under the ear, near the eye, near the anus and on the hindgut; iridophores dull; pigmented retinal epithelium pale and retina beginning to degenerate on d5 , tectal degeneration on d4 and d5. | Kelsh et al. 1996, Heisenberg et al. 1996, Furutani-Seiki et al. 1996 |
| jam jam |
tr254a | d2 | embryonic lethal | d1, quiver, d2, reduced muscle striation, blood not passing on from heart ventricles, heart ventricles are slightly smaller. d3, move slowly. | Granato et al. 1996a, Chen et al. 1996 |
| jellyfish jef |
tw37 | d3 | embryonic lethal | Tissue missing anterior to the eyes (hammerhead-like). Slightly reduced body length. Cartilaginous elements severely reduced and often absent except for two pieces at the level of the ceratohyals. No cartilaginous elements except for two pieces of cartilage at the position of the ceratohyals. The neurocranium is completely lacking. Dermal bones, like the cleithrum and the parasphenoid, as well as teeth are present. | Piotrowski et al. 1996 |
| kasper kap |
ty236a | 20som | embryonic lethal | d1, body shape like 17 hr embryo, arrested development, all organs arrested. d2, no pigmentation, not hatched. | Kane et al. 1996a |
| kefir kef |
ta65b, tf229 (LOST) | d2 | adult viable | Reduced xanthophore pigmentation. d6, no visible xanthophore pigment, but whitish cells throughout region of xanthophores, faint granularity visible. No obvious phenotype in homozygous adults. | Odenthal et al. 1996a, Kelsh et al. 1996 |
| keinstein kei |
ts242a, tj229f, ts276e, tb213b, tc242a | d2 | embryonic lethal | Missing or tiny otoliths. mshC expression in ear weak and delocalised at 48h. | Whitfield et al. 1996 |
| kinks kik |
tl209 | d1 | adult viable | Variable bends in notochord, maybe semi-dominant . | Odenthal et al. 1996 |
| knollnase kas |
ty122 | d1 | embryonic lethal | d1, dorsal midline in anterior forebrain absent, sometimes completely collapsed brain ventricles; d2, tectum necrosis, enlarged heart cavity, slighltly curled up tail ; d3, oedema, general necrosis. | Heisenberg et al. 1996 |
| knorrig koi |
tl226d | d3 | embryonic lethal | Tissue missing anterior to the eyes (hammerhead-like). All elements are smaller but thicker but individual chondrocytes are normal-seized. Tumor-like outgrowths of chondrocytes occur along edges of all elements including the neurocranium. | Piotrowski et al. 1996 |
| korinthe kor |
tm292b | d4 | adult semiviable | Small lens, d5, lens degeneration. | Heisenberg et al. 1996, Haffter et al. 1996b |
| korken kon |
tc230 | d2 | embryonic lethal | No notochord sheath, round cells visible around the periphery of the notochord, reduced body length, jump once after touch. | Odenthal et al. 1996, Granato et al. 1996a |
| krom krm |
tc227d | d3 | adult semiviable | d3 curly pectoral fins, no other defects, difficult to raise (might be background). Homozygous adult phenotype: pectoral fins do not grow out, paired anal fins variably reduced. | van Eeden et al. 1996a, Haffter et al. 1996b |
| kugelig kgg |
tl240a, tv205c | d1 | embryonic lethal | d1, short tail, dense tail somites, reduced posterior yolk extension. | Hammerschmidt et al. 1996 |
| kurzschluss kus |
tr12 | d3 | embryonic lethal | Circulation is restricted to heart and head. No circulation in trunk and tail. | Chen et al. 1996 |
| lacklustre lcl |
ta229d | d3 | adult viable | Dull iridophores. No obvious phenotype in homozygous adults. | Kelsh et al. 1996 |
| lakritz lak |
th241 | d4 | embryonic viable | Expanded melanophores, no behavioral phenotype on d5. | Kelsh et al. 1996 |
| landing lnd |
tf21a | d1 | embryonic viable | Melanophore number reduced, remainder are tiny, or pale; by d5 the phenotype is weak, melanophores are slightly paler and greyer than in wild type, effect most pronounced in the yolk sac stripe, where in some cases the number of melanophores still is reduced. Similar to ton, but weaker, and no touch response defect. | Kelsh et al. 1996 |
| lauscher lau |
tk256a | d4 | adult viable | Expanded ears. The 5 tissue projections which should form the semicircular canals are enlarged. The tissue projections might be unable to fuse with each other. Slight tendency to circle in homozygous adults. | Whitfield et al. 1996 |
| lawine law |
ts18 | epiboly | embryonic lethal | d0, round cells at the edges of the neural tube in trunk and tail. Usually epiboly is not completed. Dominant phenotype: short and bent tail. | Kane et al. 1996 |
| lead led |
ts32 | d2 | larval lethal | Pale melanin pigmentation on d2, slightly lighter brownish melanin on d3, subtle phenotype. Form a swim bladder, but homozygous lethal as larva. | Kelsh et al. 1996 |
| legong leg |
tj201 | d1 | embryonic lethal | d1, weak heart beat and thin heart. d2, heart looks tube like, nearly silent ventricle, fibrillating atrium. | Chen et al. 1996 |
| leopard leo |
t1 (s), to29, tq270, tw28 | d99 | adult viable | Spotted adult pigmentation pattern, no phenotype in embryo. Dominant phenotypes: t1 has slightly wavy stripes; tw28 has wavy stripes; tq270 and to29 are spotted. Recessive phenotypes: t1 and tw28 are spotted, tq270 has tiny spots, to29 has few very tiny spots. Allele strength: t1<tw28<tq270<to29. t1 is spontaneous allele, usually available in pet shops. to29 has an adult tailfin deletion phenotype in the background, maybe this is linked to leo. | Haffter et al. 1996b |
| leprechaun lep |
tq236, tj222 | d4 | adult viable | d5 Small pupil, structures in the ear look retarded, more severe phenotype than in dreumes. tj222/tq236 transheterozygotes have clearly bigger pectoral fins on d5. | Heisenberg et al. 1996, Whitfield et al. 1996, van Eeden et al. 1996a |
| liliput lil |
tc232 | d99 | adult viable | Dominant adult phenotype, short body, no obvious skeletal abnormalities. | Haffter et al. 1996b |
| little ears lte |
tg414b, to27d | d3 | embryonic lethal | Small ear, balance problem, often swim sideways or upside down. | Whitfield et al. 1996 |
| locke lok |
tm138a, tj8, ts277, tl215, to237b | d1 | embryonic lethal | Curly tail down, cyst in pronephric region. | Brand et al. 1996a, Chen et al. 1996 |
| lockjaw low |
ts213 | d1 | embryonic lethal | d1, reduced number of melanophores and reduced overall head size. d3, severely reduced arches, jaw does not extend, lower jaw hanging down. Alcian blue staining: severe reduction of hyomandibular and symplectic cartilages, often ventrally displaced. Palatoquadrate looks more or less normal and contacts neurocranium in some cases. Loss and reduction of gill arches, normally gills 1, 2 and 5 present, 3 and 4 absent. Ethmoid plate reduced and often cleft anteriorly. | Schilling et al. 1996 |
| lonely atrium loa |
tu29d | d1 | embryonic lethal | d1, enlarged atrium, d2, no ventricle detectable, no circulation, edema. | Chen et al. 1996 |
| long fin lof |
t2 (s) | d99 | adult viable | Dominant and recessive adult phenotype, long fins, length of fin increases with age. Spontaneous allele t2 is usually available in pet shops. | Haffter et al. 1996b |
| lost trail los |
ty85b | d5 | embryonic lethal | Melanophore number variably reduced on posterior part of yolk sac stripe. Homozygous adults have an abnormal stripe pattern in the tail, which is somewhat reduced. | Kelsh et al. 1996 |
| lost-a-fin laf |
ty130a, tc263, tf211, tt203, tv9, tm110b, tf215a,tn217, tb241c | 1som | embryonic lethal | d0 tailbud extends off of the yolk prematurely. d1, ventral tail fin absent. Ventral tail vein often missing and sometimes forked tail tip. Weak alleles only partial absence of ventral tail fin. Allele strength: tm110b>ty130a=tc263=tt203>tf211>tv9 | Mullins et al. 1996 |
| lucky luc |
tm95c, ty18 | d2 | adult viable | Degenerating notochord, reduced body length, no obvious phenotype in homozygous adults. | Odenthal et al. 1996, Granato et al. 1996a |
| lumpazi lum |
th209b | d5 | embryonic viable | Liver necrosis. | Chen et al. 1996 |
| mach two mah |
tm127b | d2 | adult viable | d2 reduced motility, reduced striated muscle, d5 swimming improved, no obvious phenotype in homozygous adults. | Granato et al. 1996a |
| macho mao |
tt261 | d2 | embryonic lethal | d2, no touch response. d4, expanded melanophores. Nasal retinotectal axons already start arborizing in anterior tectum. | Granato et al. 1996a, Trowe et al. 1996 |
| mal profit mpt |
ts292f | d5 | adult semiviable | d5, remnants of yolk exhibit a dark brown colour. Homozygous adults are smaller than wild type. | Hammerschmidt et al. 1996 |
| masterblind mbl |
tm13 | 1som | embryonic lethal | 15 somites, no optic vesicles, delayed formation of third brain-ventricle. d1, no eyes, reduced or no telencephalon. d3, no olfactory pits; d5, reduced blood circulation, general necrosis. Expanded epiphysis. | Heisenberg et al. 1996 |
| matt mat |
ti280 | d3 | adult viable | Dull iridophores, xanthophores slightly 'fibrous' in appearance. No obvious phenotype in homozygous adults. | Kelsh et al. 1996 |
| melancholic mac |
tj19e | d4 | embryonic viable | d5 expanded melanophores, form swim bladder, but do not eat paramecia. | Kelsh et al. 1996 |
| mercedes mes |
tz209, tm305 | tailbud | adult viable | d0, tail bud stage, excess round cells ventral to the tail bud. d1 big cells in region of blood island, split tailfin, duplicated ventral melanophore stripe in tail, no obvious adult phenotype in tz209, tm305 homozygous fish frequently show a split tailfin. | Hammerschmidt et al. 1996a, van Eeden et al. 1996a, Haffter et al. 1996b, Kelsh et al. 1996 |
| merlot mot |
tm303c, tu275 | d2-d3 | embryonic lethal | Decreasing number of blood cells after 2 to 3 days of development. Allele strength: tm303c>tu275 | Ransom et al. 1996 |
| microps mic |
tm329 | d1 | adult viable | d1 smaller eye, d5 small eyes, lens relatively normal, expanded melanophores, slightly shorter than sibs. Homozygous adult phenotype: tiny eye, lens still relatively normal, expanded melanophores, short. | Heisenberg et al. 1996 |
| microtic mtc |
ta221 | d3 | embryonic lethal | Small ear, circling, jaw looks retarded but all elements present, retarded or smaller pectoral fins. Possibly a cartilage mutant. | Whitfield et al. 1996 |
| microwaved med |
tt281 | d2 | adult viable | Same embryonic phenotype as frilly fins : wavy edge of fins. In contrast to frilly fins however no visible phenotype in homozygous adults. | van Eeden et al. 1996a |
| miles apart mil |
te273, m93 | d1 | embryonic lethal | Cardia bifida, two hearts, one on each side of the embryo, bubbly tail fin. | Chen et al. 1996 |
| milky mlk |
te1a, tg2, tv10 | d2 | embryonic lethal | Xanthophores faintly yellow and granular in dorsal head, in tv10 whitish cells visible in normal positions, iridophores dull, especially on the eye, expanded melanophores, head, eye and arches reduced; te1a is slightly weaker than the other alleles. | Kelsh et al. 1996, Heisenberg et al. 1996, Schilling et al. 1996 |
| mirage mir |
tm79d | d2 | embryonic lethal | d2 melanophore number decreased posteriorly, d5 melanophores as d2, iridophore number decreased, general necrosis. | Kelsh et al. 1996, Heisenberg et al. 1996 |
| miro mio |
tm88z | d5 | Small head, beady eyes with protuding lenses, oedemic heart, defective jaw, no swimbladder. Temporal axons grow posteriorly on small, fragmented tectal neuropil. | Trowe et al. 1996 | |
| momo mom |
th211 | 1som | embryonic lethal | d0, somites fused in the midline. d1, no notochord in the trunk, no floor plate in trunk, normal notochord in the tail, variable head defects in 15% of the mutant embryos, some have very small eyes with mild cyclopia others have only slightly reduced eyes, melanophores extend all around the neural tube on d1. | Odenthal et al. 1996, van Eeden et al. 1996b, Kelsh et al. 1996, Granato et al. 1996a |
| monolith mnl |
tm121 | d1 | adult viable | One otolith. No obvious phenotype in homozygous adults. | Whitfield et al. 1996 |
| monorail mol |
tv53a | d1 | embryonic lethal | Curly tail down, floor plate on d1 indistinct or patchy, present on subsequent days. Incomplete penetrance and expressivity. | Brand et al. 1996a |
| moonshine mon |
te345, ty57, tc239b, tz276, tu244b, tb222b, tc246b, tg234 | d1 | embryonic lethal | Few or no blood cells on d1, caudal fin slightly irregular by d2; d3-d5, highly increased number of iridophores in dorsal and ventral stripes and iridophores ectopically migrated into tail region, fin is irregular in size and shape, reduced motility and striation. te345 and ty57 are the strongest alleles, tc239b is the weakest allele, with a mild pigment defect and with blood present on d1, but decreasing over time. | Ransom et al. 1996, Kelsh et al. 1996, van Eeden et al. 1996a |
| mustard mrd |
ta229c, tj204, tp72i, tn215, tk68b, tv41, tg16 | d1 | adult viable | No melanin visible in embryos. dopa staining: eyes positive, body very weakly staining. Homozygous adults are yellow with red eyes. tn215 is a weak allele. | Kelsh et al. 1996, Haffter et al. 1996b |
| nagel nag |
ta84, tb22, tl28b, tm42b, tm51, tm68, tn3, tp41a, tr3, ty58, tc8, tu27a, tn210, tm147c, tg254b, te335, tj258a, tt231, tq207, tq274, tw234, tl246, ty124b | d1 | adult viable | Bubly fins, fin necrosis. No obvious phenotype in homozygous adults. | van Eeden et al. 1996a |
| natter nat |
ta219, tl43c | d1 | embryonic lethal | d1 small and flat hindbrain ventricle, brain subdivision not distinct, smaller eyes, d2 brain subdivisions become clear but small, develop variable heart problems, e.g. cardia bifida in a fraction of the embryos, shorter embryos. tl43c is stronger, with a disorganized brain morphology on d2. | Jiang et al. 1996, Chen et al. 1996 |
| nevermind nev |
tr230b, ta229f | d2 | embryonic lethal | d2, quiver and swim only short distance, abnormal balance, swim sideways, thinner neural tube. d4, slow movements Retinotectal phenotype: Dorsal nasal axons grow in dorsal and ventral branch of the optic tract. They terminate in dorsal and ventral tectum. | Trowe et al. 1996, Granato et al. 1996a |
| nickel nkl |
tm40 | d2 | adult viable | d2, slightly paler melanophores. Subtle phenotype. No obvious phenotype in homozygous adults. | Kelsh et al. 1996 |
| nicotinic receptor nic |
tk48d, b107(g) | 20som | embryonic lethal | Completely immotile from the beginning, everything else looks normal. | Granato et al. 1996a, Westerfield et al. 1990 |
| nirvana niv |
tg229 | 20som | embryonic lethal | d1, body shape like 17h embryo, arrested development of the entire embryo. No motility. d2, no pigmentation, not hatched. | Kane et al. 1996a |
| no isthmus noi |
tu29a, tm243a, th44, tb21, ty22b, ty31z | d1 | embryonic lethal | d1, Midbrain-hindbrain-boundary missing . Tectum tiny and cerebellum absent, rhombic isthmus not formed. No Engrailed protein or pax zf-b mRNA detectable in isthmus, but normal engrailed expression in muscle pioneers. No engrailed expression in midbrain primordium at 90% epiboly. Normal expression of several markers in the hindbrain (krox20, acetylated tubulin, isl-1, 3A10 antibody). Fails to connect dorsal aorta to heart on time, onset of circulation delayed, no pronephros. Retinotectal phenotype: Temporal retinal axons terminate anterior and posterior in tectal remnant. Dorsal and ventral axons map to dorsal and ventral sides of the tectum, nasal axons to locations all over the tectum and some grow past the tectum. Linked to the pax-zfb gene. | Brand et al. 1996b, Trowe et al. 1996, Chen et al. 1996 |
| no tail ntl |
tb244e, tc41, ts260, b160 (g), b195(s) | tailbud | embryonic lethal | d0, narrow notochord primordium, d1 short, undifferentiated notochord, U-shaped somites, no tail d2, no myoseptum. Allele strength: tc41>b160,b195>tb244e>ts260. ntl is the zebrafish homologue of the mouse T (brachyury) gene. | Odenthal et al. 1996, van Eeden et al. 1996b, Granato et al. 1996a |
| noir nir |
tc22, tp89 | d5 | embryonic viable | Expanded melanophores, larvae not as active as wild type , less touch sensitive, often rest on their backs. Epiphysis and neuromasts look normal under compound microspcope (UV fluorescence, morphology). d10, not actively swimming like siblings, do not feed. | Kelsh et al. 1996, Granato et al. 1996a |
| non blond nob |
tt288 | d2 | embryonic lethal | d2, no xanthophore pigmentation. d3, reduced xanthophore pigmentation. d4, small otoliths, reduced body length. d5, generally retarded. | Odenthal et al. 1996a, Kelsh et al. 1996, Whitfield et al. 1996 |
| obelix obe |
td15, ty7, tc271d | d99 | adult viable | Dominant adult phenotype: fewer melanophore stripes, wider interstripes. Recessive adult phenotype: Stronger than dominant phenotype, fewer melanophore stripes. No obvious embryonic phenotype. Allele strength: td15>tc271d>ty7 | Haffter et al. 1996b |
| obscure obs |
to2b | d4 | adult viable | Small melanophores. Subtle phenotype. Homozygous adults have pinkish colour. | Kelsh et al. 1996, Haffter et al. 1996b |
| ogre ogr |
ta52a | 8som | embryonic lethal | 8 somites, necrosis all over the embryo, but most prominent in the brain and on top of the somites. d1, head, especially brain, necrotic (black), becoming smaller during the day, somites still detectable as muscle fibres with nuclei, poorly formed nephros, tail curling to the side late on d1. | Kane et al. 1996a |
| one-eyed-pinhead oep |
tz257, m134 | tailbud | embryonic lethal | tailbud stage, no anterior prechordal plate, presumptive head ectoderm protruding towards animal pole . 10 somites, no notochord under hindbrain, the exact extent is variable, head tissue S shaped, tail bud protrudes. d1, thin head, ears protrude, one eye at the tip of the neural tube, some have kinks in the notochord, no hatching gland, floor plate is indistinct. d3, dying. | Hammerschmidt et al. 1996 |
| otter ott |
ta76b, m628, m673 | d1 | embryonic lethal | d1, reduced brain ventricles, obscure midbrain-hindbrain boundary. d2, small eyes. d3, small otic vesicle and no inner ear structures, enlarged heart cavity, normal muscle striation. | Jiang et al. 1996, Whitfield et al. 1996 |
| overlooped olp |
ts33b | d2 | embryonic viable | Circulation slow. Heart beat normal, abnormal positioning of chambers, ventricle lies on top of atrium at a 90 degree angle, enlarged outflow tract. | Chen et al. 1996 |
| parachute pac |
tc248c, tg1a, tg299b, tj250a, tm101 | d1 | embryonic lethal | Phenotype of strong alleles: d1, brain structure severely affected, ventricles filled with rounded up cells. d2, often abnormal growth on the epidermis in the hindbrain area, associated with a region that is devoid of pigmentation.. Phenotype of weak alleles: d1, brain structure are not so severely affected, hindbrain ventricles filled with cell clumps. These cells have a filopodia-like structure. d2, abnormal growth on the epidermis in the hindbrain area, associated with a region that is devoid of pigmentation. tg1a is semiviable, most have swimbladder, but die around d10. tc248c viable. Allele strength: tm101>tj250a>tg299b>tg1a>tc248c | Jiang et al. 1996 |
| parade pde |
tj262, tv212 | d3 | adult viable | Mixed chromatophores accumulate below notochord on medial pathway, prominent in trunk and tail. | Kelsh et al. 1996 |
| pech pch |
ts292e | d1 | embryonic lethal | Melanophores very small from d1 on, collect abnormally below ear by d2; Iridophores dull and whitish, xanthophores invisible. Pigmented retinal epithelium pale and degenerating, small otoliths, slightly retarded embryo. | Kelsh et al. 1996 |
| pekinese pek |
td14 | d3 | embryonic lethal | Tissue missing anterior to the eyes. All elements are kinked. Similar to the hammerhead phenotype but parachordals and occipital arches not as much reduced. Short pectoral fins that start to necrose on d5. | Piotrowski et al. 1996 |
| penner pen |
to6 | d5 | embryonic lethal | Abnormal cell growth especially visible around the pectoral fins and below the arches. | van Eeden et al. 1996a |
| pepita pep |
tl23, th204a (lost) | d1 | embryonic lethal | Very pale melanin, especially in melanophores; by d5 many melanophores are small, spot-like, and beginning to collect abnormally around the eyes and under the ear, iridophores very dull; th204a is stronger than tl23. | Kelsh et al. 1996 |
| petroglyph pet |
tm65 | d1 | embryonic viable | Recessive phenotype: Very spindly melanophores, usually pale on d2, fully recovered by d5. Dominant phenotype: Slightly spindly, slightly pale melanophores on d2, normal by d4. | Kelsh et al. 1996 |
| pewter pew |
tm79b | d2 | adult viable | Melanophores slightly paler, blackish. No obvious phenotype in homozygous adults. | Kelsh et al. 1996 |
| pfeffer pfe |
tc227b, tq211, tg17, te220, tm236b, tg283a | d2 | adult viable | No xanthophores or reduced number of xanthophores. Recessive adult phenotype: No blue stripes in fins, fading stripes in body. Dominant adult phenotype: Interrupted blue stripes. Allele strengths: tm236b>tq211>tg283a | Odenthal et al. 1996a, Kelsh et al. 1996, Haffter et al. 1996b |
| piggytail pgy |
dty40, tc227a, ta206(lost),dti216c, tx223, tm124 | tailbud | embryonic lethal | d0, tailbud extends off of the yolk prematurely. Somites extend more laterally. d1, Ventral tail fin absent. Ventral tail vein often missing and sometimes forked tail tip. Weak alleles only show partial absence of ventral tail fin. In strong alleles, the tail axis is twisted on itself ('piggytail'). Heterozygous ty40 and ti216c mothers, but not fathers, result in a dominant phenotype in their heterozygous offspring: loss of ventral tail fin. Allele strength: dty40>dti216c>tc227a>ta206>tx223 | Mullins et al. 1996 |
| pile-up pup |
tm9a, tm88a (lost), tv215, te256 (lost), tk62 | d1 | embryonic lethal | Pale melanin, especially in melanophores, pigmented retinal epithelium palest in te256 and tv215 . By d5 some melanophores are small and spot-like, beginning to collect abnormally under the ears and near the eyes, in piles in dorsal stripe and on gut, iridophores very dull, whitish. tk62 is slightly weaker than the other alleles. | Kelsh et al. 1996 |
| pinfin pif |
tm95b, tj16, te262d, tr274 | d1 | adult viable | Bubbly fins. Homozygous adults have reduced fins. | van Eeden et al. 1996a, Haffter et al. 1996b |
| pinotage pnt |
tq209 | d2 | adult viable | Hypochromic blood after 2 days of development. Number of blood cells to between 25% to 50% of normal levels. | Ransom et al. 1996 |
| pinscher pic |
to216z | d5 | embryonic lethal | Dorsal retinotectal axons grow on both optic tracts. Dorsally projecting axons leave the contralateral tectum and grow towards the ipsilateral tectum. Massive arches; all present, but short and thick. | Trowe et al. 1996, Karlstrom et al. 1996, Schilling et al. 1996 |
| pipe heart pip |
tq286e | d2 | embryonic lethal | d2, weak beat of both heart chambers, ventricle nearly silent, edema, no circulation. d3, smaller eyes and head, silent ventricle, tube-shaped atrium and ventricle, general necrosis. | Chen et al. 1996 |
| pipe tail ppt |
te1c, tc271b (lost), ta98, ti265, th278 | tailbud | embryonic lethal | d0, Somites are thinner and extend more laterally. Notochord is broader and undulating. Length from head process to tailbud is shorter. Tailbud is smaller. 13-20 somites, somites are less V-shaped. d1, approximately 60%-75% of normal body length, varying among alleles. Both trunk and tail are shorter. Short and thick yolk tube. End of tail is missing. All somites present, but region posterior to last somite is absent. Somites are compressed along antero-posterior axis and less V-shaped. Dorsal aorta extends to end of tail. Pigmentation gap in tail missing. Notochord appears wider, especially in posterior tail. d5, mouth short, similar to hammerhead. All arches present. | Hammerschmidt et al. 1996, Piotrowski et al. 1996 |
| pirueta pir |
tq213b | d2 | embryonic lethal | d2, curly tail up in a long swoop. d5, phenotype somewhat variable. | Brand et al. 1996a |
| pistachio pio |
tc276c, to75a, tb202, ts41, tk17 | d2 | embryonic lethal | No xanthophore pigmentation, xanthophores very faintly granular, iridophores very dull, expanded melanophores, head, eyes and arches strongly reduced. All alleles similar in strength. | Kelsh et al. 1996, Heisenberg et al. 1996, Schilling et al. 1996 |
| polished pol |
ti224, ty32b, ty124d | d2 | embryonic lethal | Very pale xanthophores, but granularity still there, melanophores initially pale, by d5 many melanophores are small, spot-like and collect abnormally under ear, on hindgut and stomach; from d4 on, staccato-like movements. | Kelsh et al. 1996 |
| polka plk |
tg290, ty105b | d1 | embryonic lethal | d1, very weak or no heart beat, strongly dented yolk, d2, heart is not beating, isolated cell contraction in the atrium, enlarged atrium, small venticle, no circulation. | Chen et al. 1996 |
| poltergeist plt |
tb216 | 12som | embryonic lethal | 12 to 15 somites, necrosis all over the embryo, but most prominent in the brain and on top of the somites. Mutant embryos die at 20 to 22h. | Kane et al. 1996a |
| punkt pun |
tl39, tk22, te380, tp219d | d1 | embryonic lethal | Very pale melanin, especially in melanophores; d5, few melanophores, most small and spot-like, collect abnormally under the ear, in piles in dorsal stripe, near anus and on hindgut, iridophores very dull, whitish, pigmented retinal epithelium slightly paler than in wild type; weak notochord degeneration. Dominant phenotype: grey or cloudy yolk, most prominent in tp219d , which is the strongest allele. | Kelsh et al. 1996, Odenthal et al. 1996 |
| puzzle puz |
tp49c | d2 | embryonic lethal | d2, melanophores paler, number of melanophores decreased, but in unusual gradient: most normal dorsally, strongest phenotype ventrally. By d4, melanophore phenotype largely recovered, highly reduced iridophores, xanthophores less prominent, ear abnormal. d5, general necrosis, no jaw and arches. | Kelsh et al. 1996, Whitfield et al. 1996, Schilling et al. 1996 |
From: Haffter, P., Granato, M., Brand, M., Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., van Eeden, F. J. M., Jiang, Y.-J., Heisenberg, C.-P., Kelsh, R. N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C. and Nüsslein-Volhard, C. (1996). The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123, 1-36.
A-H | Q-Z | Phenotypic groups
last modified
2006-08-29