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Tübingen 1 Screen A - H

Genes identified in the Tübingen 1 Screen: A - H

I-P | Q-Z | Phenotypic groups

accordion acc	tc249a, tq206, tp72x, tn218b, tm286, ty20, ti284a	d1	embryonic lethal	After touch uncoordinated contraction of trunk muscles resulting in a contracted wavy notochord, 10 to 20% shorter than wild type.	Granato et al. 1996a, Odenthal et al. 1996
acerebellar ace	ti282a	5som	embryonic lethal	No rhombic isthmus, but tectum present and normal. No Engrailed protein or pax zf-b mRNA detectable at 24h in the midbrain, but some pax zf-b mRNA detectable at 100% epiboly in the midbrain primordium. Engrailed protein and pax zf-b mRNA is normal in other places. Defective circulation, small ear, edema.	Brand et al. 1996, Whitfield et al. 1996, Trowe et al. 1996
after eight aei	tg22a, tg249, tr233, tm223	10som	adult viable	Somite formation stops after seventh or eighth somite. Viable and fertile, no obvious phenotype in homozygous adults.	van Eeden et al. 1996
albino alb	b4 (s), ti9, tj20e, tm83a, ti225, tr282, tf31	d1	adult viable	No melanin visible. Homozygous adults are yellow with red eyes.	Kelsh et al. 1996, Streisinger et al. 1986, Haffter et al. 1996b
alligator ali	tm342	d2	embryonic lethal	d2, reduced touch response, can swim when water is swirled.	Granato e al. 1996a
another long fin alf	ty86d	d99	adult viable	Dominant adult phenotype: long fins, tail hangs down, finrays are irregular. No embryonic phenotype, no obvious recessive phenotype different from the dominant phenotype found.	Haffter et al. 1996b
aquabat aqb	to260b	d2	embryonic lethal	d2, some cell death in spinal cord, necrosis in brain. Jaw region reduced. d3, tail slightly curled up, reduced circulation, brain necrosis. d4, Tail curls up and around to the head. d5, general necrosis.	Brand et al. 1996a
asterix ase	tt269	d99	adult viable	Dominant adult phenotype: Fewer and wider melanophore stripes. Recessive adult phenotype: Stronger than dominant phenotype. No obvious embryonic phenotype, segregates independently of obe.	Haffter et al. 1996b
astray ast	ti272z, te284,te378, tl231	d5	embryonic viable	Nasal and some temporal retinal ganglion cell axons make errors after chiasm and terminate in forebrain, in the tectum or posterior to the tectum in the hindbrain. No obvious morphological phenotype. Early growing retinal ganglion cell axons do not fasciculate at the midline at 36h, they meet at the midline but then grow in various incorrect directions. Some retinal ganglion cell axons reach their appropriate positions on the tectum.	Karlstrom et al. 1996
atlantis atl	tc234b, ty86a, tm48, tg1b	d1	adult viable	d1, one or two extra folds in hindbrain, the extra folds disappear gradually. d2, phenotype no longer apparent.	Jiang et al. 1996
avalanche ava	tm94	epiboly	embryonic lethal	Recessive phenotype: Cells round up and fall off of the yolk during epiboly (hence the name). Dominant phenotype: d0, round cells at the edges of the neural tube in the trunk and the tail. Tailbud flattened on yolk. Sometimes epiboly is not completed. d1, short tail is the most consistent trait. Often additional cells dorsal over the brain, sometimes look like additional tecta. Often looks like two partially fused neural tubes. Notochord and floor plate in trunk almost normal.	Kane et al. 1996
babyface bab	tb210	d2	embryonic lethal	d2, severe flathead with massive reduction of brain and eyes. Not retarded. Alcian blue staining: All arches affected. Meckel's and palatoquadrate reduced. Arches 5-7 usually absent. Reduced neurocranium.	Schilling et al. 1996, Heisenberg et al. 1996
backstroke bks	tm317d	d1	embryonic lethal	No otoliths, impaired balance and motility. d5, resting and swimming on side or even upside down.	Whitfield et al. 1996
bajan baj	tf247	d1	embryonic lethal	Uncoordinated contraction of trunk muscles, eventually completely immotile.	Granato et al. 1996a, Odenthal et al. 1996
balloonhead bad	tp71d	d2	embryonic lethal	Brain abnormally shaped, reduced hindbrain, head short and high. No neurocoel in trunk region, embryo bent in trunk. Enlarged heart cavity.	Brand et al. 1996a
bandoneon beo	tu230 (lost), tp221, tm115, tf242, ta92, tw38f, ta86d	d1	embryonic lethal	After touch uncoordinated contraction of trunk muscles resulting in a contracted wavy notochord, slightly bent up, 10 to 20% shorter than wild type.	Granato et al. 1996a, Odenthal et al. 1996
banshee ban	tf221	20som	embryonic lethal	d1, body shaped like a 17h embryo, arrested development of all organs. Embryos telephone shaped. d2, no pigmentation, not hatched.	Kane et al. 1996a
bashful bal	tp82, tm220a, tr259, tf235, tv36, tt206, tp86, tm267a, tf209, to265, tc245a, tq210, tb244f, tc248f, tr203, m190	d1	embryonic lethal	Disorganized brain morphology, less differentiated notochord, less V-shaped somites, reduced body length. Notochord and somite phenotype is variable in strength, strong alleles have a thinner notochord which is slightly undulating, weak alleles do not display any obvious notochord phenotype. Retinotectal projection phenotype: axons leave optic nerve and tract to grow rostrally and sometimes to the ipsilateral tectum. Allele strength: tc245a , tc248f, tm267a, tr259 >tm220a>tf235, tf209, tt206>tq210, tr203	Odenthal et al. 1996, Karlstrom et al. 1996
beamter bea	tm98, to202, tw212b	6som	adult viable	Somite formation stops after four somites. No obvious phenotype in homozygous adults, homozygotes are fertile.	van Eeden et al. 1996
bedimmed bed	to240	d3	adult viable	Dull iridophores. Homozygous adults have pale greenish-blue stripes.	Kelsh et al. 1996
belladonna bel	tv42z	d5	adult viable	Retinal axons grow directly to ipsilateral tectum only. Normal map on tectum. Can be sorted as abnormal pigmented retinal epithelium and iridiophores around lens, "pupils" appear big. 50% to 75% of the sorted embryos show the retinotectal phenotype. Post optic commissure does not form, anterior commissure forms normally.	Karlstrom et al. 1996
biber bib	tb8	15som	embryonic lethal	d1, unstructured brain. Somites indistinct. Vacuolated undifferentiated material in tail.	Hammerschmidt et al. 1996
big ears bge	tr216e, tb233c	d5	embryonic viable	Expanded otic capsules.	Whitfield et al. 1996
big head bid	to15c	d1	adult viable	d1, abnormally folded tectum, enlarged midbrain. No visible adult phenotype.	Jiang et al. 1996
blanched bch	ti282b	d1	embryonic lethal	Pale, small melanophores collect abnormally below ear, a few on the hindgut. Iridophores dull, xanthophores pale but still granular. d2, reduced or no response to touch. d4, tectum degeneration, small eyes. By d5 small fish, heart oedema, brain and eyes small, small otoliths, retarded embryo.	Kelsh et al. 1996, Heisenberg et al. 1996, Furutani-Seiki et al. 1996, Whitfield et al. 1996
blasen bla	ta90	d1	adult viable	d1, bubbly fins. d3, pigment gap in tail fin reduced or absent. Expanded melanophores.	van Eeden et al. 1996a
bleached blc	ts23, ty89, th204b	d1	embryonic lethal	Melanophores all small and collect abnormally under the ear, on hindgut and around eye. Number of melanophores reduced. Iridophores dull, whitish, xanthophores pale, but granular. Pigmented retinal epithelium is pale; eye degenerates. Tectal degeneration from d4 on, small otoliths, retarded embryo by d5.	Kelsh et al. 1996, Heisenberg et al. 1996, Furutani-Seiki et al. 1996, Whitfield et al. 1996
bleich bli	tl240c	d2	embryonic viable	Melanophores mostly pale, a few melanophores are small and spot-like by d2. Melanophores may collect abnormally under ear and on hindgut by d5. Iridophores dull in body, but normal on eyes. Xanthophores slightly paler and often less granular.	Kelsh et al. 1996
blobbed blo	tm289	d1	adult viable	Notochord curved up in tip of tail, neurocoel ends in a blob. No obvious phenotype in homozygous adults.	Odenthal et al. 1996
blowout blw	tc294z	d5	adult semiviable	One or both eyes evaginated or "blown out" into brain. The blown out structure has all the normal eye layers and in some embryos cells mix with brain cells. Ipsilateral projection of retinal ganglion cell axons in some cases. Axons from the normal eye turn after crossing the midline, perhaps at the location where they hit the abnormally located pigmented epithelium.	Karlstrom et al. 1996
blumenkohl blu	tc257z	d5	embryonic lethal	Retinotectal projection phenotype: Nasal axons terminate in a cauliflower like fashion, covering a large area of the posterior tectum.	Trowe et al. 1996
blurred blr	tk12, tp90, tu29c, tp223a, tm297, tx3, tq262b	d1	embryonic lethal	Melanophores pale in body and pigmented retinal epithelium. Melanophore number decreased by d5, and many melanophores small and spot-like, a few pale or fragmented. Pigmented retinal epithelium degenerating by d5. Melanophores collect abnormally under ear and near the eyes and hindgut. Iridophores dull and whitish on d2, almost invisible and very few on d5; tx3 has strongest pigmented retinal epithelium degeneration phenotype, but tm297 and tp90 may have stronger melanophore phenotype; tx3, tm297 and tp90 are the strongest alleles, tu29c is the weakest.	Kelsh et al. 1996, Heisenberg et al. 1996
bouillabaisse bob	tu255a	d1	embryonic lethal	Abnormal cell groups on epidermis, cells floating around in chorion, skin falling off. Dead after 48h.	van Eeden et al. 1996a
boxed ears bxe	tz214c	d2?		Smaller ear, apparently uninflated, but chambering of the ear and otoliths normal.	Whitfield et al. 1996
boxer box	tm4, tm70g, tg308c, te242, tm317c, tw24, tp67z, to232	d4	embryonic lethal	d4, ventral branchial arches reduced, mouth open, mandibular and hyoid retarded, but normal. Pectoral fins short. d5, reduced motility, fish make litttle jumps. Alcian blue staining: all elements present. Meckels points a little dorsally. Cartilaginous elements formed by many small, irregularly formed cells. Thus elements look more compact. Retinotectal projection phenotype: Dorsal axons grow along dorsal and ventral optic tract. Dorsal axons entering the tectum through the dorsal branch first continue their dorsal trajectory on the tectum, but later turn and terminate ventrally.	Trowe et al. 1996, van Eeden et al. 1996a, Schilling et al. 1996, Karlstrom et al. 1996, Granato et al. 1996a, Whitfield et al. 1996
braindead brd	tl21, ty91, tl41, tp41z, tv59y, tm46y, ty103z, tm42z, tc265z	d3	embryonic lethal	Tectum specific degeneration starting on d3, projection of retinal axons on tectum looks bushy ("struppig" phenotype).	Trowe et al. 1996, Furutani-Seiki et al. 1996
brassy bry	tm111	d1	adult viable	Pale melanin, especially in melanophores. Iridophores dull and white, especially on body. Homozygous adults have red eyes.	Kelsh et al. 1996, Haffter et al. 1996b
breakdance bre	tb218	d2	adult viable	Heart ventricle beats about half as frequently as atrium (atrium:ventricle=2:1 ), reduced circulation.	Chen et al. 1996
bressot bst	tp223b	d2	embryonic lethal	Reduced xanthophore pigmentation.	Odenthal et al. 1996a, Kelsh et al. 1996
brie bri	tg211b, tj226, tu269, tm42c	d2	adult viable	Reduced xanthophore pigmentation, d4 brownish cells visible in head, trunk and tail, flat greenish fluorescent cells, mainly ventral, fluorescence fades after some time, cells not as dendritic. Allele strength: tj226>tu269	Odenthal et al. 1996a, Kelsh et al. 1996
bumper bum	to20, tm127d, tg413	d4	adult viable	d4, degenerating lens to variable degrees. In severe cases the iris closes completely. Homozygous adult fish have expanded melanophores and bump into aquarium walls.	Heisenberg et al. 1996, Haffter et al. 1996b
buzz-off buf	te228, ts215, ti209, th234, ts246	d2	embryonic lethal	d2, buzz along bottom of dish, reduced muscle striation, reduced motility.	Granato et al. 1996a
bypass byp	tu244c, tn209	d2	embryonic lethal	Position of yolk is shifted more posteriorly. Blood stream does not go over yolk.	Chen et al. 1996
casanova cas	ta56	d1	embryonic lethal	Cardia bifida, two hearts, one on each side of the embryo. Gradually losing motility: normal motility on d1, immotile on d2.	Chen et al. 1996
chablis cha	tu242e, tu245	d4	embryonic viable	Decreasing blood count starting on d2, no blood on d4, homozygous semilethal.	Ransom et al. 1996
chameleon con	tf18b, tu214 (lost), ty60, tm15a, th6	20som	embryonic lethal	At 15 somites floor plate very indistinct but present, neurocoel irregularly formed. d1, Neural tube thinner. Horizontal myoseptum septum absent in tail, no lateral stripe of melanophore pigmentation. No muscle pioneers (birefringence, engrailed staining). Blood cells stuck behind anus. Dorsal tail aorta missing or not properly developed, dorsal vein present and often filled with blood cells. Somites without myoseptum. Tail curled down. d2, thin neural tube, cells somewhat more roundish. Eyes turned in posteriorly, looks like tegmentum and/or ventral diencephalon is less wide, heart cavity enlarged. Touch response impaired, often almost insensitive. d4, Jaw is variably developed. tm15a is the strongest allele. Retinotectal phenotype: retinal ganglion cell axons make pathfinding errors within the eye, tending to grow along the equator. When axons leave the eye they project to the ipsilateral or contralateral tectum. Partially linked to wir.	Brand et al. 1996a, van Eeden et al. 1996b, Chen et al. 1996, Karlstrom et al. 1996, Piotrowski et al. 1996
chardonnay cdy	te216	d2	adult viable	Hypochromic blood after 2d of development. Variably decreasing number of blood cells to between 50% to 75% of normal levels.	Ransom et al. 1996
chianti cia	tu25f	d3	adult viable	Hypochromic blood after 3 days of development. Number of blood cells between 50% to 75% of normal levels.	Ransom et al. 1996
choco cco	ta87, ty86b	d2	embryonic lethal	Xanthophores unpigmented and faintly granular, iridophores dull, eyes small.	Kelsh et al. 1996, Heisenberg et al. 1996
choker cho	tm26	d2	embryonic lethal	No lateral melanophore stripe, dorsal and ventral stripes joined behind head, somites less V-shaped than wt, horizontal myoseptum variably reduced, dent in posterior hindbrain visible from d3 onwards.	Kelsh et al. 1996, van Eeden et al. 1996b
clorix clx	tj244	d2	embryonic lethal	d3, reduced xanthophore pigmentation. d4, small otoliths, reduced motility. d5, xanthophores only slighly reduced, small melanophores accumulate around ear.	Odenthal et al. 1996a, Kelsh et al. 1996, Whitfield et al. 1996, Granato et al. 1996a
cold-light cot	tv205b, tz264 (lost)	d2	embryonic lethal	Xanthophore pigmentation faint, melanophores pale, number of melanophores seems slightly decreased. Melanophores become small and spot-like by d5 and collect abnormally below ear and on hindgut.	Kelsh et al. 1996
colourless cls	t3 (s), tw2, tw11	d1	embryonic lethal	Almost no melanophores and xanthophores, few iridophores, abnormal ear with tiny otoliths; swim poorly.	Kelsh et al. 1996, Whitfield et al. 1996, Granato et al. 1996a
cookie coo	tw33, tm130f	d2	adult semiviable	Xanthophores pale and weakly granular, dull iridophores, eyes reduced in size. No obvious phenotype in homozygous adults.	Kelsh et al. 1996, Heisenberg et al. 1996
cosinus cos	tw216b	d5		S-shaped body axis	Brand et al. 1996a
crash test dummy ctd	tc36, tl43b, tw38g	d1	embryonic lethal	Undulated notochord, severe distortion of body axis, reduced body length.	Odenthal et al. 1996
crocodile cro	tw212d	d4	embryonic lethal	d4 reduced touch response: repetetive touch stimulations reduce response: 1. touch : just jumps; 2. touch: just shiver; 3. touch : no reaction. d5 expanded melanophores	Granato et al. 1996a
curly up cup	ty30, tp85a, tc321, tg266d	d1	embryonic lethal	d1, curly tail up, spiraling.	Brand et al. 1996a
cyclops cyc	tf219, te262c, b16 (s), b213 (g), b229 (g), m101, m294	10som	embryonic lethal	No floor plate, reduced prechordal plate, variably fused eyes, tail curled down. Allele strength: tf219 like b16,te262c is much weaker with incomplete eye fusion and patchy floor plate. te262c,	Brand et al. 1996a, Karlstrom et al. 1996, Heisenberg et al. 1996, Hatta et al. 1991
dackel dak	to273b, tw25e, tf205, to79c	d3	embryonic lethal	Complex phenotype: Tiny pectoral fins, all arches shorter and thicker than in wild type. Lower jaw further caudal and ventral, abnormal head shape, more severe than boxer. Inner ear structures seem retarded, ear is expanded on d5. Retinotectal projection phenotype: dorsal axons grow along dorsal and ventral optic tract. Dorsal axons entering the tectum through the dorsal branch first continue their dorsal trajectory on the tectum, but later turn and terminate ventrally.	van Eeden et al. 1996a, Trowe et al. 1996, Karlstrom et al, 1996, Schilling et al. 1996, Whitfield et al. 1996
dandruff ddf	ta50, tj6, ti251, tc289	12som	adult viable	12 somites, abnormal head shape, round cells on head. d1, abnormal looking cell growth on skin and fins, prominent on yolk sac, isolated cells floating around in chorion. d3, labyrinthine epidermal cells present but irregularly organized. Embryos recover during development, form swimbladders, although abnormal cell growth is still visible on yolk-sac. No obvious phenotype in homozygous adults.	van Eeden et al. 1996a
däumling dml	tn8	d5	adult semiviable	Dominant adult phenotype: very short body. Reduced number of vertebrae, fusions of vertebrae in posterior half of the adult skeleton. Embryos have a slightly reduced body length on d5, delayed swimbladder formation.	Haffter et al. 1996b
deadly seven des	tc225, tp37, th35b, tw239, tm145, tc239c, tx201, tj247, to15e, tc322b	10som	adult semiviable	Somite formation stops after seventh or eighth somite. No obvious phenotype in homozygous adults .	van Eeden et al. 1996
delayed fade dfd	tj241a	d3	embryonic lethal	Melanophores become pale or small and spot-like on d3, and collect under ear, around eye, in piles in dorsal stripe and on hindgut. Xanthophores may be more compact too. d5, eyes slightly reduced in size and tectum slightly degenerating.	Kelsh et al. 1996, Heisenberg et al. 1996, Trowe et al. 1996, Furutani-Seiki et al. 1996
detour dtr	ts269, te370a, tm276b	d1	embryonic lethal	d1, Floor plate and neurocoel indistinct, eyes turned slightly inwards. Curly tail down. d2, eyes turned in more strongly posteriorly. d4, lower jaw hanging down. Retinotectal axons grow ipsilateral or ipsilateral and contralateral, phenotype not found in all of mutants sorted by the floor plate phenotype. Correct map on ipsilateral tectum. Variable retinal ganglion cell axon defects at 36h seen by acetylated tubulin antibody labeling, post optic commissure does not form, anterior commissure does form, retinal ganglion cell axons sometimes cross ( with huge growth cones) and sometimes grow ipsilateral after "exploring" toward midline. te370a is the strongest allele with respect to the neural tube and eye phenotype.	Brand et al. 1996a, Karlstrom et al. 1996, Piotrowski et al. 1996
dimmed dim	te214	d2	embryonic lethal	Dull iridophores.	Kelsh et al. 1996
dino din	tm84, tt350	5som	embryonic lethal	d0 Ventralized. Rounded up cells in an enlarged tailbud region, notochord thin and prematurely ending or absent in posterior region, small eye placodes. d1 small eyes, often enlarged brain ventricles, edema just behind yolk extension filled with blood, tail very short. d2 necrotic.	Hammerschmidt et al. 1996a, Odenthal et al. 1996
dirty nose dns	te350	d1	adult viable	d1, degeneration of anterior prechordal plate visible as shadows under eyes, visible only in frontal view, no hatching gland, collapsed brain ventricles; d2, no sign of necrosis, epidermis over hindbrain has outgrowths; d3, not hatched, round cells on hindbrain. Mutant progeny of two homozygous adults look the same as progeny from two heterozygous carriers.	Hammerschmidt et al. 1996, Furutani-Seiki et al. 1996
diwanka diw	tz290, tv205a, ts286	d1	embryonic lethal	After touch uncoordinated contraction of trunk muscles resulting in a contracted wavy notochord, slightly bent up, 10 to 20% shorter than wild type, small eyes and enlarged hindbrain ventricle.	Granato et al. 1996a, Odenthal et al. 1996
doc doc	tt202, tt258, tc233a	10som	embryonic lethal	d0, narrow notochord primordium. d1, short, less differentiated notochord, U-shaped somites. d2, no horizontal myoseptum. d5, notochord in tip of tail. Allele strength: tt258>tc233a>tt202. tt202 is temperature sensitive: at low temperature the notochord is present over the entire length. The doc gene product is required in notochord cells autonomously.	Odenthal et al. 1996, van Eeden et al. 1996b, Granato et al. 1996a
dog-eared dog	tp85b, to15b, tm90b, tc257e	d1	embryonic lethal	Abnormal morphogenesis of ear, small otoliths, retarded jaw and lateral line system. mshC expression absent or very weak in ear at 48h. Number of hair cells in ear reduced; cristae appear to be absent.	Whitfield et al. 1996
dolphin dol	ti230g	d3	embryonic lethal	Tissue anterior to the eyes is reduced. Upper and lower jaws protrude and therefore resemble a beak. Meckel's cartilage and the ceratohyal consist of smaller more irregularly aligned cells. Distal end of the ceratohyal fuses with the basihyal. Dorsal pole of the hyosymplectic is broader. Ceratobranchials and hypobranchials are difficult to distinguish from each other. The ethmoid plate of the neurocranium is pointed instead of rounded.	Piotrowski et al. 1996
dopey dop	tr222b, tz226, tm18a, m475	d1	embryonic lethal	d1, short, less differentiated notochord, U-shaped somites, no fin outgrowth. d2, dead. Allele strength: tm18a (no heartbeat)>tm18a3tz226 (little heartbeat).	Odenthal et al. 1996
dreumes dre	tm146d	d4	adult viable	Small pupil, subtle ear phenotype, tissue projecting vertically from the middle to the top of the ear is not detectable. d30, fish stay very small, variable eye defects, normal balance, lack the unpaired anal fin.	Heisenberg et al. 1996, Whitfield et al. 1996, van Eeden et al. 1996a
dropje drp	tr256	d4	adult semiviable	Expanded melanophores in embryos and homozygous adults.	Kelsh et al. 1996, Haffter et al. 1996b
duckbill dul	tu45	d4	embryonic lethal	d4, reduced eyes and brain. Flathead-like. Jaw protrudes. Alcian blue staining: Anterior arches are normal, although ceratohyals slightly reduced. Variable loss of gills in segments 4-7.	Schilling et al. 1996, Heisenberg et al. 1996
duesentrieb dus	tq250	d2	embryonic lethal	Reduced muscle striation, reduced motility.	Granato et al. 1996a
ear plugs eps	tt286c	d4	adult viable	Pear shaped ears, small otoliths, weak circling behavior.	Whitfield et al. 1996
earache era	tc288c	d5	adult viable	Abnormal ear shape. Homozygous adults have expanded melanophores and could be blind (big pupils).	Whitfield et al. 1996, Heisenberg et al. 1996
edison edi	tl35, tv4 (LOST), tc245c, tp62, to255b, tr276, tp67b, tl245, tt232, tz253 (LOST), tk232a	d2	embryonic lethal	Reduced xanthophore pigmentation, xanthophore pigment almost absent, blue fluorescence of yolk and all cells in strong alleles at 24h, some irregularely distributed fluorescent cells mainly in the tail, blue fluorescence accumulates in the gut and gets excreted.	Odenthal et al. 1996a, Kelsh et al. 1996
einstein eis	ta29, to228, tc7c, tz256, tw224, tp17, tg238c, ti230c (LOST), ts284, td204g, tg203d, ti272c, tc317a, tt272b, te296f, ts209 (LOST),to236	d1	adult viable	One otolith, no obvious phenotype in homozygous adults.	Whitfield et al. 1996
eisspalte ele	ty77e	d1	embryonic lethal	d1, dent in hindbrain posterior to the cerebellum. d2, curved tail. d3, small eyes and head, enlarged brain ventricles, retarded. d4, begin to die.	Jiang et al. 1996
eselsohr eso	tp85d	d3	embryonic viable	Subtle abnormal morphogenesis of anterior semicircular canal in ear.	Whitfield et al. 1996
esrom esr	th222, tg5, th36b, tb241a, te250, te279, tg265a, tj236, ts208, tp203, tn207b, te376, te275, tf4z	d3	embryonic lethal	d2, no xanthophore pigmentation visible, d4 reduced xanthophore pigmentation visible in head, trunk and tail. Retinotectal projection phenotype: Many retinal axons stop growing to tectum and form "onion" right behind papille. If nasal axons reach tectum, they frequently stop anteriorly. If they grow posteriorly, the termination zone is usually greatly increased.	Odenthal et al. 1996a, Kelsh et al. 1996, Karlstrom et al. 1996, Trowe et al. 1996
expander exp	tu12	d1	embryonic lethal	Uncoordinated contraction of trunk muscles resulting in a contracted wavy notochord, 10 to 20% shorter than wild type.	Granato et al. 1996a, Odenthal et al. 1996
facelift fac	tj13	d2	embryonic lethal	d2, reduced iridophores. d4, flathead-like, slightly reduced eyes and brain. Alcian blue staining: All arches present but slightly reduced. Ceratohyals often kinked and reduced. Sometimes lacking gill arch 6.	Schilling et al. 1996, Heisenberg et al. 1996
fade out fad	tm63c, tp94c, tc7b, tg14 (lost), tk224 (lost)	d1	embryonic lethal	melanophores pale, become small and spot-like, accumulate below ear, on and around eye, on hindgut and in piles in dorsal stripe; pigmented retinal epithelium pale on d3, then degenerates; tp94c and tm63c are the strongest alleles, tk224 is the weakest allele.	Kelsh et al. 1996, Heisenberg et al. 1996
fading vision fdv	th236a	d1	adult viable	Melanophores pale and fuzzy, mostly small and spot-like by d5, collect under ear, in piles in dorsal stripe, around eye and on hindgut. pigmented retinal epithelium is white, retina is degenerating by d5. Homozygous adults are pale and yellowish, no eye pigment, but normal pigmentation pattern, very small eyes, possibly blind.	Kelsh et al. 1996, Heisenberg et al. 1996, Haffter et al. 1996b
fakir far	tm154	d2	adult viable	d2, no apparent motility in chorion, respond only to strong stimulus. d3, muscle striation visible. d5, escape response reduced.	Granato et al. 1996a
fata morgana fam	te267	d4	adult viable	Expanded melanophores, phenotype dissappears as the fish mature.	Kelsh et al. 1996
faulpelz fap	tc222, ta218	d5	embryonic lethal	Reduced muscle striation, reduced motility.	Granato et al. 1996a
faust fau	tm236a	d1	embryonic lethal	Cardia bifida, two hearts and heart cavities, one on each side.	Chen et al. 1996
feta fet	ty107	d2	adult viable	d2 reduced xanthophore pigmentaion, yellow brownish colour present in head, trunk and tail, very little fluorescence detectable in the tail and the trunk.	Odenthal et al. 1996a, Kelsh et al. 1996
fibrils unbundled fub	b45 (g?), b126 (g), tu44a, ta51b	20som	embryonic lethal	d1 immotile, collapsed brain ventricles, d2 reduced muscle striation, weak heart beat.	Granato et al. 1996a, Felsenfeld et al. 1990
finless fls	te370f	d20	adult semiviable	No adult fins.	Haffter et al. 1996b, van Eeden et al. 1996a
flat head fla	ty76, th5b, ta53c, tf21c, tu255e	d3	embryonic lethal	Some gill arches reduced (arches 3,4 and 7), arches 5 and 6 absent, flat head. Teeth on 7th arch present. Reduced eyes and brain. Transient brain degeneration. Ceratohyal points dorsally in some cases. Basihyal in most cases absent. Some form a swim bladder.	Schilling et al. 1996, Heisenberg et al. 1996, Furutani-Seiki et al. 1996
floating head flh	n1 (s), tk241, tm229, m614	1som	embryonic lethal	No notochord, ventrally fused somites in the trunk, separated somites in the tail, small patches of floor plate only, melanophores extend all around the neural tube on d1. flh is the zebrafish homologue of the Xnot gene. tk241 and tm229 are single point mutations aminoterminal to the homeodomain, causing premature stop codons .	Odenthal et al. 1996, Talbot et al. 1995, Kelsh et al. 1996, van Eeden et al. 1996b, Granato et al. 1996a
flotte lotte flo	ti262c	d4	embryonic lethal	d4 small eyes, necrosis in tectum and dorsal forebrain. d5 stomach thin-walled, no intestinal folds.	Chen et al. 1996, Heisenberg et al. 1996
fransen fra	tc17, tk219a, tr206b, tm55	d1	adult semiviable	Fin necrosis, no obvious phenotype in homozygous adults.	van Eeden et al. 1996a
frascati frs	tg221, tg280a, tq223, tm130d	d2-d4	embryonic viable	d2, hypochromic blood, decreasing number of blood cells, forms a swimbladder, but most die before reaching adult, semilethal. Allele strength: tg280a>tq223>tm130d>tg221.	Ransom et al. 1996
frayed fyd	tj2b	d2	adult viable	Necrosis of all fins, pigmentation gap in tail missing, reduced body length.	van Eeden et al. 1996a
freckles frk	th35d	d2	embryonic lethal	Melanophores initially pale, by d5 some small and spot-like, a few collect abnormally under the ear; iridophores dull, but somewhat variable between different individuals, especially on eye.	Kelsh et al. 1996
freixenet frx	tu271	d2	embryonic lethal	Porphyria, decreasing blood count, fluorescent blood. d5, black spots in liver and fluorescent gut, due to clearing of lysed erythrocytes.	Ransom et al. 1996
frilly fins frf	tf5, th42, tp34, ty69, tp207, tm317a, tz252	d2	adult viable	d2 wavy edge of tail and pectoral fins. Homozygous adults are shorter and have reduced fin outgrowth and kink at head-trunk boundary.	van Eeden et al. 1996a, Haffter et al. 1996b
frozen fro	to27c	20som	embryonic lethal	d1, twitch weakly only when touched. Twitching of jaw and pectoral fins after strong stimulation. Musculature below jaw reduced or absent. No muscle striation detectable under compound microscope. Enlarged heart cavity, circulation normal.	Granato et al. 1996a
fullbrain ful	tq279, m133, m157	d2	embryonic lethal	d1 slightly collapsed brain ventricles, slightly inward turned eyes. d2 mild cyclopia, dented yolk, melanophores in dorsal and ventral stripes of anterior trunk displaced laterally and in some places, number of melanophores in lateral stripe strongly decreased, rough appearance of skin; retarded and necrosing embryos by d3.	Jiang et al. 1996, Kelsh et al. 1996, Whitfield et al. 1996
fused somites fss	ti1 (s), te314a	2som	adult viable	No visible somite borders in early somite stages, later irregular borders. Reduced viability.	van Eeden et al. 1996
gammler gam	tf207d	d5	embryonic lethal	Liver necrosis.	Chen et al. 1996
gaping mouth gap	tw220c	d4	embryonic lethal	Mouth permanently open. Short pectoral fins. All cartilaginous elements present. Meckel's often fused to palatoquadrate but normal length. Hyosymplectic of second arch is reduced dorsally to facial foramen. Ceratohyal always points ventrally. Neurocranium narrower than in wild-type (trabeculae closer together). Rarely more than one tooth per side.	Schilling et al. 1996
geist get	ty111, ti240	d3	embryonic lethal	d4, tissue in front of eyes missing (hammerhead-like). 75% of normal body length. All cartilaginous elements present but chondrocytes are more irregularly aligned. Extracellular matrix of chondrocytes only stains faintly with alcian blue.	Piotrowski et al. 1996
ghoul ghl	tu274, to52b, tq251	d1	embryonic lethal	d1, body shape like 20 hr embryo, arrested development of the entire embryo, development of all organs arrested. d2, long skinny tail, no pigmentation except sometimes weakly in the eye, often not hatched.	Kane et al. 1996a
golden gol	b1 (s), b13(g), b204(g), tg271, ty213, t14m (m), m592,	d1	adult viable	No melanin visible on d1, but from d2 onwards pale brown melanin visible in all melanophores and the eyes. Homozygous adults have reduced melanophore pigmentation.	Kelsh et al. 1996, Streisinger et al. 1986, Haffter et al. 1996b
goosepimples gsp	tk34a, tk38, tt221	d2	embryonic viable	d2 cells round up on epidermis and fins, fins are irregularly reduced, phenotype variable, reduced size of embryo, head-trunk angle frequently too big, forms swim bladder, late lethal.	van Eeden et al. 1996a
gossamer ger	tc11c	d2	embryonic lethal	Melanophores thin, elongated or spot-like on d2; by d5 brain, jaw and arches degenerating, melanophores either spindly, or small and spot-like.	Kelsh et al. 1996, Furutani-Seiki et al. 1996, Schilling et al. 1996
grenache gre	tr219	d4	embryonic lethal	Hypochromic blood after 4 days of development. Number of blood cells to about 50% of normal levels.	Ransom et al. 1996
grumpy gup	ti228b, tj229a, tx221, tl17b, tm61, tp42, tg210, m189	15som	embryonic lethal	d1, short, less differentiated notochord, less V-shaped somites, disorganized brain morphology. d2, enlarged brain ventricles, starting brain necrosis. By d5, general necrosis except in tx221, which is the weakest allele. In tx221 retinotectal axons turn rostrally after crossing the midline or grow towards the ipsilateral tectum. Allele strengths: tj229a>ti228b>tx221.	Odenthal et al. 1996, Karlstrom et al. 1996
haken hkn	ta211	d1	embryonic lethal	Dominant curly tail down. After hatching about half of them stretch out.	Brand et al. 1996a
half baked hab	dtv43	epiboly	embryonic lethal	Recessive phenotype: d0, epiboly arrest at 50% or 60% epiboly. Development proceeds, e.g. the prechordal plate reaches the animl pole, but the embryo never extends normally, and usually dies as the yolk cell lyses. Dominant phenotype: Heterozygous offspring from carrier males show enlarged hatching glands, which is easiest to see on late d1; Heterozygous offspring from carrier females have slow epiboly and sometimes do not complete epiboly. on d1, these embryos have a ragged hatching gland, often periderm cells ball up and sometimes fall off.	Kane et al. 1996
half stoned hst	ta229a, ta51d	d1	adult semiviable	Reduced number of otoliths, sometimes small otoliths.	Whitfield et al. 1996
hammerhead ham	te296c, to16	d3	embryonic lethal	d3 tissue anterior to eyes is missing (hammerhead-like). 20% shorter body length and reduced pectoral fins. All cartilaginous elements present but kinked and consisting of small, less orderly aligned cells. Mesodermally derived neurocranium, parachordals and occipital arches are strongly reduced or absent.	Piotrowski et al. 1996
hanging out hot	tq213d, tl20b, tv49b, tl17d, to273e	d4	embryonic lethal	Permanently open mouth. All elements of the pharyngeal skeleton point ventrally but do not exhibit any structural defects. Possible jaw muscle defect.	Piotrowski et al. 1996
happy hap	tc229, te239, tr278, ty230, tk56a, tm285	d1	embryonic lethal	d1 short, less differentiated notochord, less V-shaped somites, no pectoral fin outgrowth. d2 dead. Allele strength: tm285 (no heartbeat, short)>>ty230, te239>tc229 (almost normal circulation, longer)	Odenthal et al. 1996
harpy hrp	ti245	d1	embryonic lethal	d1, body shape like 20 hr embryo, arrested development of the entire embryo. d2, long skinny tail, no pigmentation , often not hatched.	Kane et al. 1996a
head on hen	tq251f, tt209b, tu248	d3	embryonic lethal	Tissue anterior to eyes is missing. Embryos one third of normal length. All elements of the jaw and gill arches are present but kinked. Embryos have the same phenotype as hammerhead except that the occipital arches are present. Head and neurocranium shorter. The trabeculae are located at a right angle to the ethmoid plate. All elements consist of smaller cells.	Piotrowski et al. 1996
headphones hph	tr15	d4	adult viable	Expanded otic capsules.	Whitfield et al. 1996
heart attack hat	te313	20som	embryonic lethal	d2, immotile, no circulation, slightly enlarged heart cavity.	Granato et al. 1996a, Chen et al. 1996, Whitfield et al. 1996
heirloom hei	tl225a	d3	embryonic viable	Dull iridophores; number of iridophores may be decreased, and lateral patches seem smaller, yolk sac stripe thinner and broken.	Kelsh et al. 1996
helderziend hez	tq291	d4	adult semiviable	Lens is clear instead of greenish, does not reflect the light as strongly as the normal lens. Relatively weak hammerhead phenotype and slightly reduced body length.	Heisenberg et al. 1996
hermes hem	tt286b, tt227b	d2		Reduced muscle striation, reduced motility.	Granato et al. 1996a
hertz her	ts299c	d5	embryonic lethal	d5 uncoordinated movement with low amplitude of tail flip, some swim upside down, d5 some with swb; some have expanded melanophores.	Granato et al. 1996a
herzschlag hel	tg287	20som	embryonic lethal	d1, no motility, weak heartbeat, small brain ventricles, d2, starting general necrosis.	Granato et al. 1996a, Chen et al. 1996
hiphop hip	tx218	d1	embryonic viable	d1, weak heart beat, rate is not consistent. Most have dented yolk. d2, Heart beats at 3:1 ratio (atrium:ventricle). Sometimes, heart beating pauses for a second or two and results in regurgitation. Possibly semi-dominant. Homozygous larvae die within two weeks.	Chen et al. 1996
hoover hoo	tn213	d3	embryonic lethal	First two arches reduced. Meckel's fused to palatoquadrate. Mouth stays open. Ceratohyal sometimes in two pieces. Small pieces of additional cartilage close to basihyal. Similar to the sturgeon phenotype. Posterior arches not affected.	Piotrowski et al. 1996
hypersensitive hps	tc288d	d5	adult viable	Extra neuromasts along the rostral half of the trunk lateral line. Homozygous adults have pigmentation defect. Melanin pigmentation is absent in the region of the trunk where the lateral line organs come from.	Whitfiel et al. 1996

From: Haffter, P., Granato, M., Brand, M., Mullins, M. C., Hammerschmidt, M., Kane, D. A., Odenthal, J., van Eeden, F. J. M., Jiang, Y.-J., Heisenberg, C.-P., Kelsh, R. N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C. and Nüsslein-Volhard, C. (1996a). The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123, 1-36.

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